减轻对脑内皮层微电极神经炎症反应的抗炎方法。
Anti-inflammatory Approaches to Mitigate the Neuroinflammatory Response to Brain-Dwelling Intracortical Microelectrodes.
作者信息
Bedell Hillary W, Capadona Jeffrey R
机构信息
department of Biomedical Engineering, Case Western Reserve University, School of Engineering, 2071 MLK Jr. Drive, Wickenden Bldg, Cleveland OH 44106, USA.
Advanced Platform Technology Center, L. Stokes Cleveland VA Medical Center, Rehab. R&D, 10701 East Blvd. Mail Stop 151 AW/APT, Cleveland OH 44106, USA.
出版信息
J Immunol Sci. 2018;2(4):15-21. doi: 10.29245/2578-3009/2018/4.1157. Epub 2018 Aug 3.
Abstract
Intracortical microelectrodes are used both in basic research to increase our understanding of the nervous system and for rehabilitation purposes through brain-computer interfaces. Yet, challenges exist preventing the widespread clinical use of this technology. A prime challenge is with the neuroinflammatory response to intracortical microelectrodes. This mini-review details immunomodulatory strategies employed to decrease the inflammatory response to these devices. Over time, broad-spectrum anti-inflammatory approaches, such as dexamethasone and minocycline, evolved into more targeted treatments since the underlying biology of the neuroinflammation was elucidated. This review also presents studies which examine novel prospective targets for future immunomodulatory targeting.
摘要
皮层内微电极既用于基础研究以增进我们对神经系统的理解，也用于通过脑机接口实现康复目的。然而，存在一些挑战阻碍了这项技术在临床上的广泛应用。一个主要挑战是对皮层内微电极的神经炎症反应。这篇小型综述详细介绍了为减少对这些装置的炎症反应而采用的免疫调节策略。随着时间的推移，由于神经炎症的潜在生物学机制得到阐明，诸如地塞米松和米诺环素等广谱抗炎方法逐渐演变为更具针对性的治疗方法。这篇综述还介绍了一些研究，这些研究探讨了未来免疫调节靶向的新的潜在靶点。
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