• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Anti-inflammatory Approaches to Mitigate the Neuroinflammatory Response to Brain-Dwelling Intracortical Microelectrodes.减轻对脑内皮层微电极神经炎症反应的抗炎方法。
J Immunol Sci. 2018;2(4):15-21. doi: 10.29245/2578-3009/2018/4.1157. Epub 2018 Aug 3.
2
Understanding the Effects of Both CD14-Mediated Innate Immunity and Device/Tissue Mechanical Mismatch in the Neuroinflammatory Response to Intracortical Microelectrodes.了解CD14介导的固有免疫以及设备/组织机械不匹配在对皮层内微电极的神经炎症反应中的作用。
Front Neurosci. 2018 Oct 31;12:772. doi: 10.3389/fnins.2018.00772. eCollection 2018.
3
Differential expression of genes involved in the chronic response to intracortical microelectrodes.参与皮质内微电极慢性反应的基因的差异表达。
Acta Biomater. 2023 Oct 1;169:348-362. doi: 10.1016/j.actbio.2023.07.038. Epub 2023 Jul 26.
4
Differential expression of genes involved in the acute innate immune response to intracortical microelectrodes.参与皮质内微电极急性先天免疫反应的基因的差异表达。
Acta Biomater. 2020 Jan 15;102:205-219. doi: 10.1016/j.actbio.2019.11.017. Epub 2019 Nov 14.
5
Understanding the Role of Innate Immunity in the Response to Intracortical Microelectrodes.了解固有免疫在对皮层内微电极反应中的作用。
Crit Rev Biomed Eng. 2018;46(4):341-367. doi: 10.1615/CritRevBiomedEng.2018027166.
6
Neuroinflammatory Gene Expression Analysis Reveals Pathways of Interest as Potential Targets to Improve the Recording Performance of Intracortical Microelectrodes.神经炎症基因表达分析揭示了潜在的靶点途径，以改善脑皮层内微电极的记录性能。
Cells. 2022 Jul 30;11(15):2348. doi: 10.3390/cells11152348.
7
A graphical user interface to assess the neuroinflammatory response to intracortical microelectrodes.用于评估皮质内微电极引发的神经炎症反应的图形用户界面。
J Neurosci Methods. 2019 Apr 1;317:141-148. doi: 10.1016/j.jneumeth.2019.01.003. Epub 2019 Jan 18.
8
Depletion of complement factor 3 delays the neuroinflammatory response to intracortical microelectrodes.补体因子 3 的耗竭延迟了皮质内微电极的神经炎症反应。
Brain Behav Immun. 2024 May;118:221-235. doi: 10.1016/j.bbi.2024.03.004. Epub 2024 Mar 6.
9
Microfabricated intracortical extracellular matrix-microelectrodes for improving neural interfaces.用于改善神经接口的微纳加工皮层内细胞外基质微电极
Microsyst Nanoeng. 2018 Sep 24;4:30. doi: 10.1038/s41378-018-0030-5. eCollection 2018.
10
The effect of resveratrol on neurodegeneration and blood brain barrier stability surrounding intracortical microelectrodes.白藜芦醇对皮层内微电极周围神经退行性变和血脑屏障稳定性的影响。
Biomaterials. 2013 Sep;34(29):7001-15. doi: 10.1016/j.biomaterials.2013.05.035. Epub 2013 Jun 21.

引用本文的文献

1
Angiogenic Cell Precursors and Neural Cell Precursors in Service to the Brain-Computer Interface.用于脑机接口的血管生成细胞前体和神经细胞前体
Cells. 2025 Jul 29;14(15):1163. doi: 10.3390/cells14151163.
2
Antioxidant Dimethyl Fumarate Temporarily but Not Chronically Improves Intracortical Microelectrode Performance.抗氧化剂富马酸二甲酯可暂时而非长期改善皮层内微电极性能。
Micromachines (Basel). 2023 Oct 4;14(10):1902. doi: 10.3390/mi14101902.
3
Development of a Slow-Degrading Polymerized Curcumin Coating for Intracortical Microelectrodes.聚化姜黄素缓慢降解聚合物涂层的研制用于皮层内微电极。
ACS Appl Bio Mater. 2023 Feb 20;6(2):806-818. doi: 10.1021/acsabm.2c00969. Epub 2023 Feb 7.
4
Intracortical Microelectrode Array Unit Yield under Chronic Conditions: A Comparative Evaluation.慢性条件下皮层内微电极阵列的单位产量：一项比较评估
Micromachines (Basel). 2021 Aug 17;12(8):972. doi: 10.3390/mi12080972.
5
Soft, Conductive, Brain-Like, Coatings at Tips of Microelectrodes Improve Electrical Stability under Chronic, In Vivo Conditions.微电极尖端的柔软、导电、类脑涂层可改善慢性体内条件下的电稳定性。
Micromachines (Basel). 2021 Jun 28;12(7):761. doi: 10.3390/mi12070761.
6
Recent Advances in In Vivo Neurochemical Monitoring.体内神经化学监测的最新进展
Micromachines (Basel). 2021 Feb 18;12(2):208. doi: 10.3390/mi12020208.
7
Differential expression of genes involved in the acute innate immune response to intracortical microelectrodes.参与皮质内微电极急性先天免疫反应的基因的差异表达。
Acta Biomater. 2020 Jan 15;102:205-219. doi: 10.1016/j.actbio.2019.11.017. Epub 2019 Nov 14.

本文引用的文献

1
A Dual-layered Microfluidic System for Long-term Controlled In Situ Delivery of Multiple Anti-inflammatory Factors for Chronic Neural Applications.一种用于慢性神经应用的长期可控原位递送多种抗炎因子的双层微流控系统。
Adv Funct Mater. 2018 Mar 21;28(12). doi: 10.1002/adfm.201702009. Epub 2017 Sep 20.
2
Targeting CD14 on blood derived cells improves intracortical microelectrode performance.靶向血液来源细胞上的 CD14 可改善脑皮层内微电极性能。
Biomaterials. 2018 May;163:163-173. doi: 10.1016/j.biomaterials.2018.02.014. Epub 2018 Feb 13.
3
Closing the loop on impulsivity via nucleus accumbens delta-band activity in mice and man.通过小鼠和人类伏隔核的δ波段活动来消除冲动性。
Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):192-197. doi: 10.1073/pnas.1712214114. Epub 2017 Dec 18.
4
Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance.用 IAXO-101 抑制分化群 14 先天免疫途径可改善慢性微电极性能。
J Neural Eng. 2018 Apr;15(2):025002. doi: 10.1088/1741-2552/aaa03e.
5
Microelectrode implantation in motor cortex causes fine motor deficit: Implications on potential considerations to Brain Computer Interfacing and Human Augmentation.微电极植入运动皮层会导致精细运动缺陷：对脑机接口和人类增强的潜在考虑因素的影响。
Sci Rep. 2017 Nov 10;7(1):15254. doi: 10.1038/s41598-017-15623-y.
6
Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration.脑控肌肉刺激恢复四肢瘫痪患者的上肢运动：概念验证研究。
Lancet. 2017 May 6;389(10081):1821-1830. doi: 10.1016/S0140-6736(17)30601-3. Epub 2017 Mar 28.
7
Enhanced biocompatibility of neural probes by integrating microstructures and delivering anti-inflammatory agents via microfluidic channels.通过整合微结构并通过微流体通道递送抗炎剂来增强神经探针的生物相容性。
J Neural Eng. 2017 Apr;14(2):026008. doi: 10.1088/1741-2552/aa52dc. Epub 2017 Feb 3.
8
Reduction of the foreign body response and neuroprotection by apyrase and minocycline in chronic cannula implantation in the rat brain.在大鼠脑慢性套管植入中，腺苷三磷酸双磷酸酶和米诺环素对异物反应的减轻及神经保护作用
Clin Exp Pharmacol Physiol. 2017 Feb;44(2):313-323. doi: 10.1111/1440-1681.12703.
9
Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.在多系统萎缩的转基因模型中，减少C末端截短可减轻α-突触核蛋白病和神经退行性变。
Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9593-8. doi: 10.1073/pnas.1609291113. Epub 2016 Aug 1.
10
Brain-computer interfaces for dissecting cognitive processes underlying sensorimotor control.用于剖析感觉运动控制背后认知过程的脑机接口。
Curr Opin Neurobiol. 2016 Apr;37:53-58. doi: 10.1016/j.conb.2015.12.005. Epub 2016 Jan 19.

减轻对脑内皮层微电极神经炎症反应的抗炎方法。

Anti-inflammatory Approaches to Mitigate the Neuroinflammatory Response to Brain-Dwelling Intracortical Microelectrodes.

作者信息

Bedell Hillary W, Capadona Jeffrey R

机构信息

department of Biomedical Engineering, Case Western Reserve University, School of Engineering, 2071 MLK Jr. Drive, Wickenden Bldg, Cleveland OH 44106, USA.

Advanced Platform Technology Center, L. Stokes Cleveland VA Medical Center, Rehab. R&D, 10701 East Blvd. Mail Stop 151 AW/APT, Cleveland OH 44106, USA.

出版信息

J Immunol Sci. 2018;2(4):15-21. doi: 10.29245/2578-3009/2018/4.1157. Epub 2018 Aug 3.

DOI:10.29245/2578-3009/2018/4.1157
PMID:30854523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6404754/
Abstract

Intracortical microelectrodes are used both in basic research to increase our understanding of the nervous system and for rehabilitation purposes through brain-computer interfaces. Yet, challenges exist preventing the widespread clinical use of this technology. A prime challenge is with the neuroinflammatory response to intracortical microelectrodes. This mini-review details immunomodulatory strategies employed to decrease the inflammatory response to these devices. Over time, broad-spectrum anti-inflammatory approaches, such as dexamethasone and minocycline, evolved into more targeted treatments since the underlying biology of the neuroinflammation was elucidated. This review also presents studies which examine novel prospective targets for future immunomodulatory targeting.

摘要

皮层内微电极既用于基础研究以增进我们对神经系统的理解，也用于通过脑机接口实现康复目的。然而，存在一些挑战阻碍了这项技术在临床上的广泛应用。一个主要挑战是对皮层内微电极的神经炎症反应。这篇小型综述详细介绍了为减少对这些装置的炎症反应而采用的免疫调节策略。随着时间的推移，由于神经炎症的潜在生物学机制得到阐明，诸如地塞米松和米诺环素等广谱抗炎方法逐渐演变为更具针对性的治疗方法。这篇综述还介绍了一些研究，这些研究探讨了未来免疫调节靶向的新的潜在靶点。