Department of Surgery and Integrated Clinic - Division of Periodontics, School of Dentistry, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Department of Periodontics, University of Western São Paulo (UNOESTE), Presidente Prudente, São Paulo, Brazil.
J Clin Periodontol. 2019 Apr;46(4):457-469. doi: 10.1111/jcpe.13101.
This study evaluated the effects of 5-fluorouracil (5-FU) and cisplatin (CIS) in healthy periodontal tissues and in the early stages of experimental periodontitis (EP) in rats.
One hundred and eighty male rats were divided into three groups, which were submitted to the following systemic treatments: physiological saline solution (PSS); CIS and 5FU. Each group was subdivided into two subgroups: without (NEP) and with (EP) induction of EP. Animals were euthanized at 3, 5 and 7 days post-treatment. Histological, histometric (percentage of bone in the furcation [PBF]) and immunohistochemical (for tumour necrosis factor-α, interleukin-1β and receptor activator of nuclear factor-κB ligand) analyses were performed. Data were statistically analysed.
CIS-NEP and 5FU-NEP showed more inflammation than PSS-NEP at 3, 5 and 7 days. CIS-EP and 5FU-EP showed more inflammation and lower PBF than PSS-EP at all periods of evaluation. 5FU-EP showed lower PBF than CIS-EP at 5 and 7 days.
5-FU and CIS exacerbated periodontal inflammation and aggravated the progression of EP in its early stages.
本研究评估了氟尿嘧啶（5-FU）和顺铂（CIS）在健康牙周组织和大鼠实验性牙周炎（EP）早期阶段的作用。
将 180 只雄性大鼠分为三组，分别接受以下全身治疗：生理盐水（PSS）；CIS 和 5FU。每组进一步分为无（NEP）和有（EP）牙周炎诱导两个亚组。在治疗后 3、5 和 7 天处死动物。进行组织学、组织计量学（分叉处骨百分比 [PBF]）和免疫组织化学（肿瘤坏死因子-α、白细胞介素-1β 和核因子-κB 配体受体激活剂）分析。对数据进行统计学分析。
CIS-NEP 和 5FU-NEP 在 3、5 和 7 天时的炎症反应比 PSS-NEP 更严重。CIS-EP 和 5FU-EP 在所有评估期间的炎症反应更严重，PBF 更低。5FU-EP 在 5 和 7 天时的 PBF 低于 CIS-EP。
5-FU 和 CIS 加重了牙周炎的炎症反应，并加重了 EP 的早期进展。
