Soppa G, Theodoropoulos P, Bilkhu R, Harrison D A, Alam R, Beattie R, Bleetman D, Hussain A, Jones S, Kenny L, Khorsandi M, Lea A, Mensah Ka, Hici T N, Pinho-Gomes A C, Rogers L, Sepehripour A, Singh S, Steele D, Weaver H, Klein A, Fletcher N, Jahangiri M
Department of Cardiothoracic Surgery, St. George's Hospital , London , UK.
Ann R Coll Surg Engl. 2019 May;101(5):333-341. doi: 10.1308/rcsann.2019.0029. Epub 2019 Mar 11.
We examine the influence of variations in provision of cardiac surgery in the UK at hospital level on patient outcomes and also to assess whether there is an inequality of access and delivery of healthcare. Cardiothoracic surgery has pioneered the reporting of surgeon-specific outcomes, which other specialties have followed. We set out to identify factors other than the individual surgeon, which can affect outcomes and enable other surgical specialties to adopt a similar model.
A retrospective analysis of prospectively collected data of patient and hospital level factors between 2013 and 2016 from 16 cardiac surgical units in the UK were analysed through the Society for Cardiothoracic Surgery of Great Britain and Ireland and the Royal College of Surgeons Research Collaborative. Patient demographic data, risks factors, postoperative complications and in-hospital mortality, as well as hospital-level factors such as number of beds and operating theatres, were collected. Correlation between outcome measures was assessed using Pearson's correlation coefficient. Associations between hospital-level factors and outcomes were assessed using univariable and multivariable regression models.
Of 50,871 patients (60.5% of UK caseload), 25% were older than 75 years and 29% were female. There was considerable variation between units in patient comorbidities, bed distribution and staffing. All hospitals had dedicated cardiothoracic intensive care beds and consultants. Median survival was 97.9% (range 96.3-98.6%). Postoperative complications included re-sternotomy for bleeding (median 4.8%; range 3.5-6.9%) and mediastinitis (0.4%; 0.1-1.0%), transient ischaemic attack/cerebrovascular accident (1.7%; range 0.3-3.0%), haemofiltration (3.7%; range 0.8-6.8%), intra-aortic balloon pump use (3.3%; range 0.4-7.4%), tracheostomy (1.6%; range 1.3-2.6%) and laparotomy (0.3%; range 0.2-0.6%). There was variation in outcomes between hospitals. Univariable analysis showed a small number of positive associations between hospital-level factors and outcomes but none remained significant in multivariable models.
Variations among hospital level factors exists in both delivery of, and outcomes, following cardiac surgery in the UK. However, there was no clear association between these factors and patient outcomes. This negative finding could be explained by differences in outcome definition, differences in risk factors between centres that are not captured by standard risk stratification scores or individual surgeon/team performance.
我们研究了英国医院层面心脏手术提供情况的差异对患者预后的影响,并评估医疗保健的可及性和提供方面是否存在不平等。心胸外科率先报告了特定外科医生的手术结果,其他专科也纷纷效仿。我们着手确定除个体外科医生之外,还能影响手术结果的因素,以便其他外科专科采用类似模式。
对2013年至2016年期间英国16个心脏外科单位前瞻性收集的患者和医院层面因素的数据进行回顾性分析,这些数据通过大不列颠及爱尔兰心胸外科医师协会和皇家外科医师学院研究协作组进行分析。收集了患者人口统计学数据、风险因素、术后并发症和院内死亡率,以及医院层面因素,如病床数量和手术室数量。使用Pearson相关系数评估结果指标之间的相关性。使用单变量和多变量回归模型评估医院层面因素与结果之间的关联。
在50871例患者中(占英国病例总数的60.5%),25%的患者年龄超过75岁,29%为女性。各单位在患者合并症、床位分布和人员配备方面存在很大差异。所有医院都设有专门的心胸重症监护病床和顾问。中位生存率为97.9%(范围为96.3 - 98.6%)。术后并发症包括因出血进行的再次开胸手术(中位发生率4.8%;范围为3.5 - 6.9%)和纵隔炎(0.4%;0.1 - 1.0%)、短暂性脑缺血发作/脑血管意外(1.7%;范围为0.3 - 3.0%)、血液滤过(3.7%;范围为0.8 - 6.8%)、主动脉内球囊泵使用(3.3%;范围为0.4 - 7.4%)、气管切开术(1.6%;范围为1.3 - 2.6%)和剖腹手术(0.3%;范围为0.2 - 0.6%)。各医院的手术结果存在差异。单变量分析显示医院层面因素与结果之间有少量正相关,但在多变量模型中均无显著意义。
英国心脏手术后,医院层面因素在提供服务和手术结果方面均存在差异。然而,这些因素与患者手术结果之间没有明确关联。这一负面结果可能是由于结果定义的差异、标准风险分层评分未涵盖的各中心风险因素差异或个体外科医生/团队表现的差异所致。