Bottle Alex, Mariscalco Giovanni, Shaw Matthew A, Benedetto Umberto, Saratzis Athanasios, Mariani Silvia, Bashir Mohamad, Aylin Paul, Jenkins David, Oo Aung Y, Murphy Gavin J
Dr Foster Unit, Department of Primary Care and Public Health, School of Public Health, Imperial College, London, United Kingdom.
Leicester Cardiovascular Biomedical Research Unit & Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, United Kingdom
J Am Heart Assoc. 2017 Mar 14;6(3):e004913. doi: 10.1161/JAHA.116.004913.
Thoracic aortic disease has a high mortality. We sought to establish the contribution of unwarranted variation in care to regional differences in outcomes observed in patients with thoracic aortic disease in England.
Data from the Hospital Episode Statistics (HES) and the National Adult Cardiac Surgery Audit (NACSA) were extracted. A parallel systematic review/meta-analysis through December 2015, and structure and process questionnaire of English cardiac surgery units were also accomplished. Treatment and mortality rates were investigated. A total of 24 548 adult patients in the HES study, 8058 in the NACSA study, and 103 543 from a total of 33 studies in the systematic review were obtained. Treatment rates for thoracic aortic disease within 6 months of index admission ranged from 7.6% to 31.5% between English counties. Risk-adjusted 6-month mortality in untreated patients ranged from 19.4% to 36.3%. Regional variation persisted after adjustment for disease or patient factors. Regional cardiac units with higher case volumes treated more-complex patients and had significantly lower risk-adjusted mortality relative to low-volume units. The results of the systematic review indicated that the delivery of care by multidisciplinary teams in high-volume units resulted in better outcomes. The observational analyses and the online survey indicated that this is not how services are configured in most units in England.
Changes in the organization of services that address unwarranted variation in the provision of care for patients with thoracic aortic disease in England may result in more-equitable access to treatment and improved outcomes.
胸主动脉疾病死亡率很高。我们试图确定在英国,不必要的医疗差异对胸主动脉疾病患者观察到的区域结局差异的影响。
提取了医院事件统计(HES)和国家成人心脏手术审计(NACSA)的数据。还完成了截至2015年12月的平行系统评价/荟萃分析,以及对英国心脏外科单位的结构和流程问卷调查。对治疗率和死亡率进行了调查。HES研究中共有24548例成年患者,NACSA研究中有8058例,系统评价中来自33项研究的共有103543例。在英格兰各郡之间,首次入院后6个月内胸主动脉疾病的治疗率在7.6%至31.5%之间。未经治疗患者的风险调整后6个月死亡率在19.4%至36.3%之间。在对疾病或患者因素进行调整后,区域差异仍然存在。病例数较多的区域心脏单位治疗的患者病情更复杂,与病例数较少的单位相比,风险调整后的死亡率显著更低。系统评价的结果表明,多学科团队在病例数较多的单位提供护理可带来更好的结局。观察性分析和在线调查表明,英国大多数单位的服务配置并非如此。
改变服务组织方式,解决英国胸主动脉疾病患者护理提供中不必要的差异,可能会使治疗机会更加公平并改善结局。