Mulat Mulugeta, Pandita Archana, Khan Fazlurrahman
Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida-201306, U.P, India.
Division of Microbiology, College of Natural Science, Wollo University, Dessie, Ethiopia.
Curr Pharm Biotechnol. 2019;20(3):183-196. doi: 10.2174/1872210513666190308133429.
Globally, people utilize plants as the main source of remedy to heal various ailments. Medicinal plants have been utilized to treat ailments since the invention of modern scientific systems of medicine. The common remedy of infectious diseases mainly depends on the inhibition capacity of compounds or killing potential. The issue may give a clue for the development of a novel antimicrobial agent.
Currently, microorganisms which are resistant towards antibiotics are probably a matter of serious concern for the overall well-being of health. At the moment, new therapeutic targets aside from the microorganism wall-based activities are in progress. For instance, the autoinducer molecules produced by the quorum sensing system are used to control antibiotic resistance and biofilm formation.
This therapeutic target is well-studied worldwide, however, the scientific data are not updated and only current studies started to gain insight into its perspective as a target to struggle against infectious diseases. Microbial resistance against antimicrobial compounds is a topic of serious concern in recent time.
Hence, this paper aims to confer a current overview of the novel compounds, quorum sensing, quorum quenching, biofilm formation in the development of antibiotic resistance and an update on their importance as a potential target for natural substances.
在全球范围内，人们将植物作为治疗各种疾病的主要药物来源。自现代科学医学体系发明以来，药用植物就被用于治疗疾病。传染病的常见治疗方法主要取决于化合物的抑制能力或杀灭潜力。这个问题可能为新型抗菌剂的开发提供线索。
目前，对抗生素具有抗性的微生物可能是影响整体健康的一个严重问题。目前，除了基于微生物细胞壁的活性外，新的治疗靶点正在研究中。例如，群体感应系统产生的自诱导分子被用于控制抗生素抗性和生物膜形成。
这个治疗靶点在全球范围内都有深入研究，然而，科学数据并未更新，只有当前的研究开始深入了解其作为对抗传染病靶点的前景。微生物对抗菌化合物的抗性是近年来备受关注的一个话题。
因此，本文旨在概述新型化合物、群体感应、群体猝灭、生物膜形成在抗生素抗性发展中的作用，并更新它们作为天然物质潜在靶点的重要性。
