Wang Xiaowu, Liu Yan, Ding Yunyun, Li Mei, Gao Yong, Li Tuantuan
Department of Clinical Laboratory, The Second People's Hospital of Fuyang City, Fuyang Infectious Disease Clinical College of Anhui Medical University, Fuyang, Anhui, China.
Front Microbiol. 2025 May 19;16:1568615. doi: 10.3389/fmicb.2025.1568615. eCollection 2025.
To understand the infection status and disease spectrum distribution of patients with hospital-acquired Multidrug-resistant Organism (MDRO) Infections in an intensive care unit (ICU) before, during, and after the () Pandemic, and provide a basis for the prevention and control of hospital-acquired MDRO infections.
Data from the Second People's Hospital of Fuyang City's ICU was analyzed from three periods: pre- (January 1, 2018-December 8, 2019), during (December 9, 2019-December 7, 2022), and post- (December 8, 2022-December 31, 2023). The study compares the disease spectrum of MDRO infections patients across these periods.
The incidence density of hospital-acquired MDRO infections showed significant variation over the six-year period, with the highest density in the post- period (43.98 per 1,000 ICU days) and the lowest during the period (21.96 per 1,000 ICU days). The mortality rate associated with MDRO infections was minimized during the pandemic (2.70 per 1,000 ICU days) and rebounded in the post- period (10.66 per 1,000 ICU days). The infection rate of () increased in the post- group compared to the pre- and during- groups ( = 8.82, = 0.012). Respiratory diseases consistently ranked first pre-, during, and post- pandemic. The proportion of nervous system diseases in the post- group was lower than in the pre- and during groups ( < 0.05), while the proportions of respiratory diseases and acute abdomen were higher than in the pre- and during- groups ( < 0.05). Among ICU MDRO patient death cases, the proportion of respiratory diseases in the post- group was higher than in the pre- and during- groups ( < 0.05).
Our data show the mortality rate of hospital-acquired MDRO infections decreased during and increased after restrictions eased. The disease spectrum of MDRO-infected patients is complex and diverse. Standardized, accurate treatment and focused management of respiratory diseases are essential, along with strengthened infection prevention measures.
了解重症监护病房（ICU）医院获得性多重耐药菌（MDRO）感染患者在（）大流行前、期间和之后的感染状况及疾病谱分布，为医院获得性MDRO感染的防控提供依据。
对阜阳市第二人民医院ICU三个时期的数据进行分析：大流行前（2018年1月1日至2019年12月8日）、大流行期间（2019年12月9日至2022年12月7日）和大流行后（2022年12月8日至2023年12月31日）。该研究比较了这些时期MDRO感染患者的疾病谱。
医院获得性MDRO感染的发病密度在六年期间有显著变化，大流行后时期最高（每1千个ICU日43.98例），大流行期间最低（每1千个ICU日21.96例）。与MDRO感染相关的死亡率在大流行期间最低（每1千个ICU日2.70例），在大流行后时期反弹（每1千个ICU日10.66例）。大流行后组的（）感染率与大流行前组和大流行期间组相比有所增加（χ² = 8.82，P = 0.012）。呼吸系统疾病在大流行前、期间和之后一直排名第一。大流行后组神经系统疾病的比例低于大流行前组和大流行期间组（P < 0.05），而呼吸系统疾病和急腹症的比例高于大流行前组和大流行期间组（P < 0.05）。在ICU MDRO患者死亡病例中，大流行后组呼吸系统疾病的比例高于大流行前组和大流行期间组（P < 0.05）。
我们的数据显示，医院获得性MDRO感染的死亡率在大流行期间下降，限制放宽后上升。MDRO感染患者的疾病谱复杂多样。对呼吸系统疾病进行标准化、准确的治疗和针对性管理至关重要，同时要加强感染预防措施。
