Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, LN, China.
Curr Drug Targets. 2019;20(10):1081-1089. doi: 10.2174/1389450120666190308145346.
Human NIN1/RPN12 binding protein 1 homolog (NOB1), an RNA binding protein, is expressed ubiquitously in normal tissues such as the lung, liver, and spleen. Its core physiological function is to regulate protease activities and participate in maintaining RNA metabolism and stability. NOB1 is overexpressed in a variety of cancers, including pancreatic cancer, non-small cell lung cancer, ovarian cancer, prostate carcinoma, osteosarcoma, papillary thyroid carcinoma, colorectal cancer, and glioma. Although existing data indicate that NOB1 overexpression is associated with cancer growth, invasion, and poor prognosis, the molecular mechanisms behind these effects and its exact roles remain unclear. Several studies have confirmed that NOB1 is clinically relevant in different cancers, and further research at the molecular level will help evaluate the role of NOB1 in tumors. NOB1 has become an attractive target in anticancer therapy because it is overexpressed in many cancers and mediates different stages of tumor development. Elucidating the role of NOB1 in different signaling pathways as a potential cancer treatment will provide new ideas for existing cancer treatment methods. This review summarizes the research progress made into NOB1 in cancer in the past decade; this information provides valuable clues and theoretical guidance for future anticancer therapy by targeting NOB1.
人类 NIN1/RPN12 结合蛋白 1 同源物（NOB1）是一种 RNA 结合蛋白，在肺、肝和脾等正常组织中广泛表达。其核心生理功能是调节蛋白酶活性，并参与维持 RNA 代谢和稳定性。NOB1 在多种癌症中过度表达，包括胰腺癌、非小细胞肺癌、卵巢癌、前列腺癌、骨肉瘤、甲状腺乳头状癌、结直肠癌和神经胶质瘤。尽管现有数据表明，NOB1 过表达与癌症的生长、侵袭和不良预后有关，但这些影响背后的分子机制及其确切作用仍不清楚。一些研究已经证实，NOB1 在不同的癌症中具有临床相关性，进一步的分子水平研究将有助于评估 NOB1 在肿瘤中的作用。NOB1 已成为癌症治疗的一个有吸引力的靶点，因为它在许多癌症中过度表达，并介导肿瘤发展的不同阶段。阐明 NOB1 在不同信号通路中的作用作为一种潜在的癌症治疗方法，将为现有的癌症治疗方法提供新的思路。本文综述了过去十年中关于 NOB1 在癌症中的研究进展；这些信息为未来针对 NOB1 的抗癌治疗提供了有价值的线索和理论指导。
