Service de Chimie Bio-organique et Marquage DRF-JOLIOT-SCBM, CEA, Université Paris-Saclay, 91191, Gif-sur-Yvette, France.
Université de Poitiers, UMR-CNRS 7285, Institut de Chimie des Milieux et des Matériaux de Poitiers (IC2MP), 86073, Poitiers, France.
Angew Chem Int Ed Engl. 2019 May 6;58(19):6366-6370. doi: 10.1002/anie.201902137. Epub 2019 Mar 29.
A bioorthogonal approach is explored to release the content of nanoparticles on demand. Exploiting our recently described click-and-release technology, we developed a new generation of cleavable micelles able to disassemble through a sequential enzymatic and bioorthogonal activation process. Proof-of-concept experiments showed that this new approach could be successfully used to deliver the substances encapsulated into micelles in living cells as well as in mice by two complementary targeted strategies.
我们探索了一种生物正交方法来按需释放纳米颗粒的内容物。利用我们最近描述的点击-释放技术，我们开发了新一代可通过顺序酶促和生物正交激活过程进行解组装的胶束。概念验证实验表明，这种新方法可以成功地用于通过两种互补的靶向策略将封装在胶束中的物质递送到活细胞和小鼠中。
