1 Cardiology, Duzce University School of Medicine, Duzce, Turkey.
Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619835383. doi: 10.1177/1076029619835383.
Inflammation has been implicated in the pathogenesis of endothelial dysfunction, atherosclerosis, and microvascular coronary dysfunction. In this context, it is thought that fibrinogen, high-sensitive C-reactive protein (hsCRP), and albumin may be associated with the pathogenesis of coronary slow flow (CSF). We aimed to evaluate the ratios of fibrinogen-to-albumin and hsCRP-to-albumin in patients with CSF compared to patients with angiographically normal coronary arteries and stable coronary artery disease (CAD). In all, 65 patients with CSF, 65 patients with newly diagnosed stable CAD, and 65 control participants with angiographically normal coronary arteries were included. The coronary flow rates of all patients were determined by the Thrombolysis in Myocardial Infarction frame count method. Fibrinogen, hsCRP, and albumin levels were analyzed in all patients, and the fibrinogen-to-albumin and hsCRP-to-albumin ratios were calculated. The baseline characteristics of the 3 groups were similar. The plasma albumin level was significantly lower, whereas the fibrinogen and the hsCRP levels were significantly higher, in the CSF and CAD groups compared to the controls. The fibrinogen-to-albumin and hsCRP-to-albumin ratios were significantly higher in both the CSF and the CAD groups compared to the control group. The hsCRP-to-albumin ratio was positively correlated with the mean Thrombolysis in Myocardial Infarction frame count in the whole study population. According to the receiver-operating characteristic analysis, the efficacies of the fibrinogen-to-albumin and hsCRP-to-albumin ratios in predicting CSF were significant. The fibrinogen-to-albumin and hsCRP-to-albumin ratios, which were increased by a reciprocal change, suggest that inflammation may play a role in the pathogenesis of CSF.
炎症与血管内皮功能障碍、动脉粥样硬化和微血管性冠状动脉功能障碍的发病机制有关。在这种情况下，纤维蛋白原、高敏 C 反应蛋白（hsCRP）和白蛋白可能与冠状动脉慢血流（CSF）的发病机制有关。我们旨在评估 CSF 患者与血管造影正常的冠状动脉和稳定型冠心病（CAD）患者相比，纤维蛋白原与白蛋白和 hsCRP 与白蛋白的比值。共纳入 65 例 CSF 患者、65 例新诊断的稳定型 CAD 患者和 65 例血管造影正常的对照组患者。所有患者的冠状动脉血流率均采用心肌梗死溶栓帧数法确定。对所有患者进行纤维蛋白原、hsCRP 和白蛋白水平分析，并计算纤维蛋白原与白蛋白和 hsCRP 与白蛋白的比值。3 组患者的基线特征相似。CSF 和 CAD 组的血浆白蛋白水平显著降低，而纤维蛋白原和 hsCRP 水平显著升高。与对照组相比，CSF 和 CAD 组的纤维蛋白原与白蛋白和 hsCRP 与白蛋白的比值均显著升高。hsCRP 与白蛋白的比值与全研究人群中的平均心肌梗死溶栓帧数呈正相关。根据受试者工作特征分析，纤维蛋白原与白蛋白和 hsCRP 与白蛋白比值预测 CSF 的疗效显著。纤维蛋白原与白蛋白和 hsCRP 与白蛋白比值的倒数变化表明，炎症可能在 CSF 的发病机制中发挥作用。
