a Active Carbohydrate Research Institute, Chongqing Key Laboratory of Inorganic Functional Materials , Chongqing Normal University , Chongqing , China.
Drug Deliv. 2019 Dec;26(1):252-261. doi: 10.1080/10717544.2019.1580322.
Dextran as a drug carrier for inhibiting cancer cells effectively reduces the toxic and side effects of the drug in the biological body. Targeting improves the concentration of active substance around the target tissue, which reduces damage to other heavy organs and other normal tissues. Dextran will be a potential carrier for the delivery of antitumor drugs in the future, which provides the possibility of slow-release chemotherapy and targeted drug delivery. Herein, the preparation and drug delivery of dextran-drug complex were summarized and discussed in detail.
作为药物载体，葡聚糖能有效抑制癌细胞，降低药物在生物体内的毒性和副作用。靶向作用提高了目标组织周围活性物质的浓度，减少了对其他重要器官和其他正常组织的损伤。葡聚糖将成为未来抗肿瘤药物传递的潜在载体，为化疗药物的缓慢释放和靶向药物传递提供了可能。本文详细总结和讨论了葡聚糖-药物复合物的制备和药物传递。
