Active Carbohydrate Research Institute, Chongqing Key Laboratory of Inorganic Functional Materials, College of Chemistry, Chongqing Normal University, Chongqing 401331, China.
Active Carbohydrate Research Institute, Chongqing Key Laboratory of Inorganic Functional Materials, College of Chemistry, Chongqing Normal University, Chongqing 401331, China.
Int J Biol Macromol. 2020 Feb 15;145:827-834. doi: 10.1016/j.ijbiomac.2019.11.151. Epub 2019 Nov 19.
As a natural and renewable biological macromolecule, dextran not only has excellent biodegradability, but also has good biocompatibility. Dextran and its derivatives are functional polymers for the construction of targeted drug delivery systems. Herein, the application of dextran as prodrug and nanoparticle/nanogel/microsphere/micelle carrier for targeting drug delivery system was summarized. It is clarified that dextran is an important biomaterial with application value.
作为一种天然可再生的生物大分子，葡聚糖不仅具有优异的生物降解性，而且具有良好的生物相容性。葡聚糖及其衍生物是构建靶向药物传递系统的功能聚合物。本文综述了葡聚糖作为前药和纳米粒子/纳米凝胶/微球/胶束载体在靶向药物传递系统中的应用。阐明了葡聚糖是一种具有应用价值的重要生物材料。
