Biozentrum, University of Basel, Basel, Switzerland.
Sainsbury Wellcome Centre, University College London, London, UK.
Nat Neurosci. 2019 May;22(5):778-786. doi: 10.1038/s41593-019-0357-8. Epub 2019 Mar 11.
The interactions between neocortical areas are fluid and state-dependent, but how individual neurons couple to cortex-wide network dynamics remains poorly understood. We correlated the spiking of neurons in primary visual (V1) and retrosplenial (RSP) cortex to activity across dorsal cortex, recorded simultaneously by widefield calcium imaging. Neurons were correlated with distinct and reproducible patterns of activity across the cortical surface; while some fired predominantly with their local area, others coupled to activity in distal areas. The extent of distal coupling was predicted by how strongly neurons correlated with the local network. Changes in brain state triggered by locomotion strengthened affiliations of V1 neurons with higher visual and motor areas, while strengthening distal affiliations of RSP neurons with sensory cortices. Thus, the diverse coupling of individual neurons to cortex-wide activity patterns is restructured by running in an area-specific manner, resulting in a shift in the mode of cortical processing during locomotion.
新皮层区域之间的相互作用是流动的且依赖于状态的，但个体神经元如何与皮层的网络动力学耦合仍然知之甚少。我们通过宽场钙成像同时记录，将初级视觉（V1）和后扣带（RSP）皮层的神经元的放电活动与背侧皮层的活动进行了关联。神经元与皮质表面的不同且可重复的活动模式相关联；虽然有些神经元主要与其局部区域一起发射，但其他神经元则与远处区域的活动耦合。神经元与局部网络的相关性越强，它们与远距离区域的耦合程度就越高。由运动引起的大脑状态变化会增强 V1 神经元与更高视觉和运动区域的联系，同时增强 RSP 神经元与感觉皮层的远距离联系。因此，个体神经元与皮层活动模式的多样化耦合以特定区域的方式进行重构，导致在运动过程中皮层处理模式发生转变。
