Fernández-Cuadros Marcos Edgar, Casique-Bocanegra Luz Otilia, Albaladejo-Florín María Jesús, Gómez-Dueñas Sheila, Ramos-Gonzalez Carmen, Pérez-Moro Olga Susana
Physical Medicine and Rehabilitation Department, Hospital Universitario Santa Cristina, Madrid, Spain.
Physical Medicine and Rehabilitation Department, Fundación Hospital General de la Santísima Trinidad, Salamanca, Spain.
Clin Med Insights Arthritis Musculoskelet Disord. 2019 Mar 5;12:1179544119835222. doi: 10.1177/1179544119835222. eCollection 2019.
Since the introduction of Fluoroquinolones (FQ) in 1960s, these antibiotics have been used in airway and urinary tract infections, due to absorption, biodisponibility, posology and long half-life time properties. However, several reports state that FQ can cause tendinopathy and rupture. These adverse effects can occur within hours after initial treatment to up to 6 months after withdrawal. FQ-induced tendinopathy was first reported in 1983; since then more than 100 cases have been published. FQ usage can lead to complete tendon rupture and no more than 8 to 15 cases are reported worldwide. Most of rupture cases have been associated to corticoid use and rheumatic, vascular or renal disease. The purpose of this case report is to present the challenging diagnosis of a bilateral rupture of Achilles tendon in an old patient, because of the uncommon of the presentation and to review the current literature on such a debilitating condition.
自20世纪60年代引入氟喹诺酮类药物（FQ）以来，由于其吸收、生物利用度、剂量及半衰期长等特性，这些抗生素已被用于治疗气道和泌尿系统感染。然而，有几份报告指出，FQ可导致肌腱病和肌腱断裂。这些不良反应可在初始治疗后数小时内出现，也可在停药后长达6个月内发生。FQ诱发的肌腱病于1983年首次报道；从那时起，已有100多例病例发表。FQ的使用可导致肌腱完全断裂，全球报告的病例不超过8至15例。大多数断裂病例与使用皮质类固醇以及风湿性、血管性或肾脏疾病有关。本病例报告的目的是介绍一名老年患者双侧跟腱断裂这一具有挑战性的诊断，原因是其表现不常见，并回顾关于这种使人衰弱病症的当前文献。
