Snow G R, Anderson C
Calcif Tissue Int. 1986 Apr;38(4):217-21. doi: 10.1007/BF02556713.
We carried out a pilot project to examine the alterations in trabecular bone remodeling activity of spayed Beagle dams exposed to 0.7 mg/kg body wt/day of sodium fluoride (NaF) for a 6 month period. The results indicated that short-term NaF administration does activate trabecular bone remodeling activity by stimulating the formation of new Basic Multicellular Units (BMUs) of bone remodeling activity. However, interference with bone cell differentiation, with the functional efficiency and/or life-span of individual osteoclasts and osteoblasts followed. Cellular toxic effects appear early with NaF administration, and as such, suggest that the increases in bone mass seen early in the course of NaF treatment may be negated by prolonged administration of this substance. However, preservation of bone mass will probably result with long-term therapy, due to decreases in numbers of bone cells, in their functional efficiencies, and in their individual life-spans.
我们开展了一个试点项目，以检查接受为期6个月、每日0.7毫克/千克体重氟化钠（NaF）处理的绝育比格犬母犬小梁骨重塑活性的变化。结果表明，短期给予NaF确实通过刺激新的骨重塑活性基本多细胞单位（BMU）的形成来激活小梁骨重塑活性。然而，随后会出现对骨细胞分化、单个破骨细胞和成骨细胞的功能效率及/或寿命的干扰。给予NaF后细胞毒性作用出现较早，因此表明，在NaF治疗过程早期出现的骨量增加可能会因长期给予该物质而被抵消。然而，由于骨细胞数量、其功能效率及个体寿命的减少，长期治疗可能会导致骨量的保存。
