Snow G R, Anderson C
Calcif Tissue Int. 1986 Sep;39(3):198-205. doi: 10.1007/BF02555118.
We present the results of the static and dynamic histomorphometric analyses of parameter measurements of trabecular bone remodeling activity in nonoophorectomized, untreated oophorectomized, 17 beta-estradiol-supplemented oophorectomized, as well as progestagen-supplemented oophorectomized beagle dams. If the spayed beagle dam can be considered a model in which one may equivalate bone changes occurring in the ovarian hormone-deficient human female, we reach the following conclusions: The presence or absence of quasi-physiological levels of single ovarian hormones do affect the status of trabecular bone. The evidence indicates that the presence or absence of individual ovarian hormones do not have a simple effect on trabecular bone remodeling. Apart from affecting the numbers of new bone remodeling units (BMUs) that are initiated in unit time, their effect is seen to be extended to the working efficiency of existing osteoclasts and osteoblasts. The effect is also manifest on the total amount of work performed by the collections of osteoclasts and osteoblasts that provide the respective resorptive and formation phases of the BMU. Finally, we are led to believe that there may be a close interdependence both in physiological activity and therapeutic response between the four active bone envelopes. Such protein effects have hitherto not received their due consideration from researchers in this field.
我们展示了对未切除卵巢、未治疗的切除卵巢、补充17β-雌二醇的切除卵巢以及补充孕激素的切除卵巢的比格犬母犬小梁骨重塑活动参数测量的静态和动态组织形态计量学分析结果。如果可以将绝育的比格犬母犬视为一种模型，在该模型中可以等同于卵巢激素缺乏的人类女性中发生的骨骼变化，那么我们得出以下结论：单一卵巢激素的准生理水平的存在与否确实会影响小梁骨的状态。证据表明，个别卵巢激素的存在与否对小梁骨重塑没有简单的影响。除了影响单位时间内启动的新骨重塑单元（BMU）的数量外，它们的作用还扩展到现有破骨细胞和成骨细胞的工作效率。这种作用也体现在破骨细胞和成骨细胞集合所执行的总工作量上，这些破骨细胞和成骨细胞分别提供BMU的吸收和形成阶段。最后，我们认为四种活跃的骨包膜在生理活动和治疗反应方面可能存在密切的相互依赖关系。迄今为止，这种蛋白质效应尚未得到该领域研究人员应有的关注。
