Martin R K, Albright J P, Jee W S, Taylor G N, Clarke W R
Calcif Tissue Int. 1981;33(3):233-8. doi: 10.1007/BF02409442.
In a cross-sectional study, 154 Beagles (79 males, 74 females) ranging in age from 14 to 187 months were measured for bone mineral, bone width, and mineral-to-width ratio on the distal shaft of the right tibia using a photon absorptiometer. The measurements were evaluated with regard to age, sex and body weight. The results indicate that males were heavier than females in body weight, with weight being reduced in the older animals of both sexes. When compared on an age basis, males had more mineral, a wider tibia, and a greater mineral-to-width ratio than females. The males and females reach their peak mineral, and mineral-to-width ratio at about 6 years of age and then decline. On a body weight basis, mineral, width and mineral-to-width ratio all increase with increasing body weight, with bone width being the least affected by changes in body weight. The values for females are less than those for males in all parameters with the greatest differences occurring at the greater weights. The only variance from these observations was the greater mineral-to-width ratio in the lighter females. It is concluded that, when examining cortical bone, the Beagle is a model of age-related osteopenia, and body weight is an important consideration when explaining changes in bone mineral.
在一项横断面研究中，使用光子吸收仪对154只年龄在14至187个月之间的比格犬（79只雄性，74只雌性）右侧胫骨远端骨干的骨矿物质、骨宽度和矿物质与宽度比进行了测量。对测量结果按年龄、性别和体重进行了评估。结果表明，雄性比雌性体重更重，且两性中年龄较大的动物体重减轻。按年龄比较时，雄性比雌性具有更多的矿物质、更宽的胫骨和更大的矿物质与宽度比。雄性和雌性在约6岁时达到其矿物质和矿物质与宽度比的峰值，然后下降。按体重比较时，矿物质、宽度和矿物质与宽度比均随体重增加而增加，其中骨宽度受体重变化的影响最小。在所有参数中，雌性的值均小于雄性，在体重较大时差异最大。这些观察结果的唯一差异是较轻雌性的矿物质与宽度比更大。得出的结论是，在检查皮质骨时，比格犬是年龄相关性骨质减少的模型，并且在解释骨矿物质变化时体重是一个重要的考虑因素。
