Hartenstein R
MMW Munch Med Wochenschr. 1978 Sep 1;120(35):1127-32.
The results of basic research of proliferation kinetics and pharmacokinetics as well as comparative clinical studies led to the development of therapeutic principles for malignant diseases. Thus polychemotherapy is to be preferred to monotherapy in most types of disease. To prevent primary resistance only those cytostatics should be combined which have been proved effective or could be expected to be effective individually. The relative cell cycle specificity of cytostatics should be taken into account by combination of drugs acting at different phases of the tumor cell cycle. The different growth behavior of tumor and normal tissues suggest the use of intermittent stoss therapy for the regeneration of normal tissue in the therapy-free interval.
增殖动力学和药代动力学的基础研究结果以及比较临床研究促成了恶性疾病治疗原则的发展。因此，在大多数疾病类型中，联合化疗比单一疗法更可取。为防止原发性耐药，仅应联合使用已被证明有效或预期单独有效化疗药物。通过联合作用于肿瘤细胞周期不同阶段的药物，应考虑化疗药物的相对细胞周期特异性。肿瘤组织和正常组织不同的生长行为提示在无治疗间隔期使用间歇性冲击疗法促进正常组织再生。
