Hadi Amir, Ghaedi Ehsan, Moradi Sajjad, Pourmasoumi Makan, Ghavami Abed, Kafeshani Marzieh
Department of Clinical Nutrition, School of Nutrition & Food Sciences, Food Security Research Center , Isfahan University of Medical Sciences, Isfahan, Iran.
Halal Research Center of IRI, FDA, Tehran, Iran.
Horm Metab Res. 2019 Mar;51(3):157-164. doi: 10.1055/a-0841-6638. Epub 2019 Mar 12.
Melatonin is a physiological indoleamine secreted from the pineal gland into the bloodstream. This hormone has antioxidant effects in cardiovascular disease, but the evidence regarding its effects on blood pressure (BP) has not been conclusive. Therefore, we assessed the impact of melatonin supplementation on systolic BP (SBP) and diastolic BP (DBP) through a systematic review and meta-analysis of available randomized controlled trials (RCTs). Medline, Scopus, Web of Science, Cochrane library, and Google scholar (until May 2018) were searched to identify potential RCTs with information on melatonin supplementation and BP. Mean Differences (MD) were pooled using a random-effects model. Standard methods were used for assessment of heterogeneity, sensitivity analysis, and publication bias. Pooling 5 RCTs (6 treatment arms) together identified significant reduction for SBP (MD: -3.43 mmHg, 95% confidence interval (CI): -5.76 to -1.09, p=0.004) and DBP (MD: -3.33 mmHg, 95% CI: -4.57 to -2.08, p<0.001) after supplementation with melatonin compared with control treatment. The sensitivity analysis indicated that the results were robust. We did not observe any evidence regarding publication bias. The findings of this meta-analysis support the overall favorable effect of melatonin supplementation on BP regulation.
褪黑素是一种从松果体分泌进入血液循环的生理性吲哚胺。这种激素在心血管疾病中具有抗氧化作用，但其对血压（BP）影响的证据尚无定论。因此，我们通过对现有随机对照试验（RCT）进行系统评价和荟萃分析，评估补充褪黑素对收缩压（SBP）和舒张压（DBP）的影响。检索了Medline、Scopus、科学网、Cochrane图书馆和谷歌学术（截至2018年5月），以确定有关补充褪黑素和血压信息的潜在RCT。采用随机效应模型汇总平均差（MD）。采用标准方法评估异质性、敏感性分析和发表偏倚。汇总5项RCT（6个治疗组）发现，与对照治疗相比，补充褪黑素后SBP（MD：-3.43 mmHg，95%置信区间（CI）：-5.76至-1.09，p=0.004）和DBP（MD：-3.33 mmHg，95%CI：-4.57至-2.08，p<0.001）显著降低。敏感性分析表明结果可靠。我们未观察到任何发表偏倚的证据。这项荟萃分析的结果支持补充褪黑素对血压调节的总体有利作用。
