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泰国肥胖症手术治疗重度肥胖合并糖尿病患者的成本效益评估

Cost-Effectiveness Evaluation of Bariatric Surgery for Morbidly Obese with Diabetes Patients in Thailand.

作者信息

Viratanapanu Ithiphon, Romyen Chavalit, Chaivanijchaya Komol, Sornphiphatphong Sikarin, Kattipatanapong Worawit, Techagumpuch Ajjana, Kitisin Krit, Pungpapong Suppa-Ut, Tharavej Chadin, Navicharern Patpong, Boonchayaanant Patchaya, Udomsawaengsup Suthep

机构信息

Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Faculty of Pharmaceutical Science, Chulalongkorn University, Bangkok, Thailand.

出版信息

J Obes. 2019 Feb 3;2019:5383478. doi: 10.1155/2019/5383478. eCollection 2019.

Abstract

BACKGROUND

Bariatric surgery is a choice for treatment in morbidly obese patients with type 2 diabetes mellitus (DM type 2) who have inadequate diabetes control with only medical treatment. However, bariatric surgery requires highly sophisticated equipment, and thus the cost of surgery seems to be very high following the procedure compared with the cost of conventional diabetes care. This raises the question of whether bariatric surgery is cost-effective for morbidly obese people with diabetes in Thailand.

OBJECTIVE

To perform a cost-effectiveness evaluation of bariatric surgery compared with ordinary treatment for diabetes control in morbidly obese DM type 2 patients in Thailand.

METHODS

Cost-effectiveness study was conducted, using a combination of decision tree and Markov model in analysis. Treatment outcomes and healthcare costs were incurred by data from literature review and retrospective cohort in King Chulalongkorn Memorial Hospital from September 2009 to March 2016 for the conventional and bariatric surgery group, respectively. One-way sensitivity was used for analysis of the robustness of the model. Cost-effectiveness was assessed by calculating incremental cost-effectiveness ratios (ICERs). Monetary benefits at a threshold of 150,000 to 200,000 Thai baht (THB) per quality-adjusted life-year (QALY) based on the Thailand gross domestic products (GDP) value was regarded as cost-effectiveness of bariatric surgery.

RESULTS

Bariatric surgery significantly improves the clinical outcome including long-term diabetes remission rate, hemoglobin A1C, and body mass index (BMI). The incremental cost per QALY of bariatric surgery compared with the medication control is 26,907.76 THB/QALY which can consider bariatric surgery as a cost-effective option.

CONCLUSIONS

Use of bariatric surgery in morbidly obese with DM type 2 patients is a cost-effective strategy in Thailand's context.

摘要

背景

对于仅通过药物治疗无法有效控制糖尿病的重度肥胖2型糖尿病(T2DM)患者,减肥手术是一种治疗选择。然而,减肥手术需要高度精密的设备,因此与传统糖尿病护理成本相比,手术后的手术成本似乎非常高。这就引发了一个问题,即减肥手术对泰国患有糖尿病的重度肥胖人群是否具有成本效益。

目的

对泰国重度肥胖T2DM患者进行减肥手术与普通糖尿病控制治疗的成本效益评估。

方法

进行成本效益研究,分析中采用决策树和马尔可夫模型相结合的方法。分别根据2009年9月至2016年3月朱拉隆功国王纪念医院传统手术组和减肥手术组的文献综述和回顾性队列数据得出治疗结果和医疗成本。采用单向敏感性分析模型的稳健性。通过计算增量成本效益比(ICER)评估成本效益。根据泰国国内生产总值(GDP)值,每质量调整生命年(QALY)150,000至200,000泰铢(THB)的货币效益被视为减肥手术的成本效益。

结果

减肥手术显著改善了临床结果,包括长期糖尿病缓解率、糖化血红蛋白和体重指数(BMI)。与药物控制相比,减肥手术每QALY的增量成本为26,907.76泰铢/QALY,这可将减肥手术视为一种具有成本效益的选择。

结论

在泰国的背景下,对重度肥胖的T2DM患者使用减肥手术是一种具有成本效益的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56f6/6377984/bcbd063adc94/JOBE2019-5383478.001.jpg

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