Eyeington Christopher T, Ancona Paolo, Osawa Eduardo A, Cutuli Salvatore L, Eastwood Glenn M, Bellomo Rinaldo
1 Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia.
2 Department of Intensive Care Research, Austin Hospital, Melbourne, Australia.
Anaesth Intensive Care. 2019 Jan;47(1):69-75. doi: 10.1177/0310057X18811962. Epub 2019 Feb 19.
Modern near-infrared spectroscopy technology is increasingly adopted to measure cerebral tissue oxygen saturation. However, the normal range of cerebral tissue oxygen saturation in adults with such technology is unknown. We sought to measure cerebral tissue oxygen saturation in healthy volunteers using the novel O3 Regional Oximetry® device (Masimo Corporation, Irvine, CA, USA) and assess its relationship with key physical and haemodynamic characteristics. For ≥5 minutes, we continuously recorded cerebral tissue oxygen saturation, pulse oximetry, cardiac index and mean arterial pressure. We assessed for differences in cerebral tissue oxygen saturation between hemispheres, sex, skin type, comorbidity or smoking status, and for associations between cerebral tissue oxygen saturation and age, height, weight, SpOand haemodynamic parameters. We recorded >32,000 observations in 98 volunteers aged 22 to 60 years, including 41 (42%) males. One-fifth had one or more co morbidities ( n=22, 22.5%), one-tenth were either current or former-smokers ( n=13, 13%), and most had a Fitzpatrick skin type of 3 or lower ( n=84, 86%). The mean combined average cerebral tissue oxygen saturation was 67.6% (95% confidence interval 66.8%-68.6%). We found statistically significant differences in cerebral tissue oxygen saturation according to hemisphere and an association between cerebral tissue oxygen saturation and mean arterial pressure and cardiac index. The combined average cerebral tissue oxygen saturation in 98 healthy volunteers was 67.6% with a narrow confidence interval and no combined average cerebral tissue oxygen saturation was below 56%. We also observed statistically significant yet quantitatively small cerebral tissue oxygen saturation differences between hemispheres, and an association between cerebral tissue oxygen saturation and mean arterial pressure and cardiac index.
现代近红外光谱技术越来越多地被用于测量脑组织氧饱和度。然而，使用该技术时成脑组织氧饱和度的正常范围尚不清楚。我们试图使用新型O3区域血氧饱和度仪（美国加利福尼亚州尔湾市Masimo公司）测量健康志愿者的脑组织氧饱和度，并评估其与关键身体和血流动力学特征的关系。持续≥5分钟，我们连续记录脑组织氧饱和度、脉搏血氧饱和度、心脏指数和平均动脉压。我们评估了半球、性别、皮肤类型、合并症或吸烟状况之间脑组织氧饱和度的差异，以及脑组织氧饱和度与年龄、身高、体重、SpO和血流动力学参数之间的关联。我们记录了98名年龄在22至60岁志愿者的超过32000次观察结果，其中包括41名（42%）男性。五分之一的人有一种或多种合并症（n=22，22.5%），十分之一的人是当前吸烟者或既往吸烟者（n=13，13%），大多数人的菲茨帕特里克皮肤类型为3或更低（n=84,86%）。平均合并后的脑组织氧饱和度为67.6%（95%置信区间66.8%-68.6%）。我们发现，根据半球不同，脑组织氧饱和度存在统计学上的显著差异，并且脑组织氧饱和度与平均动脉压和心脏指数之间存在关联。98名健康志愿者的合并平均脑组织氧饱和度为67.6%，置信区间较窄，且合并平均脑组织氧饱和度均未低于56%。我们还观察到半球之间脑组织氧饱和度存在统计学上显著但数量上较小的差异，以及脑组织氧饱和度与平均动脉压和心脏指数之间的关联。
