Durham University, Stockton Road, Durham, DH1 3LE, UK.
Nanoscale. 2019 Mar 21;11(12):5209-5214. doi: 10.1039/c9nr00976k.
Computational particokinetics models become essential in the design and interpretation of in vitro nanoparticle toxicology assays involving submerged adherent cell cultures. Yet, none of the current models offers the possibility of addressing the delivered dose of high-aspect ratio nanoparticles, including nanorods, nanotubes, and nanofibers. Here we present a straightforward method that lends this ability to any of the models used currently.
在设计和解释涉及浸没贴壁细胞培养的体外纳米颗粒毒理学测定时，计算颗粒动力学模型变得至关重要。然而，目前尚无任何模型能够解决高纵横比纳米颗粒（包括纳米棒、纳米管和纳米纤维）的给药剂量问题。在这里，我们提出了一种简单的方法，可以为当前使用的任何模型赋予这种能力。
