Unrue Emily L, Cline Abigail, Collins Alexandra, Nguyen Vu H, Pelle Michelle T, Blake Patrick, Feldman Steven R
Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Dermatol Online J. 2019 Feb 15;25(2):13030/qt3vn1z0s2.
Phototherapy is effective in treating psoriasis and other skin conditions. However, clinic-based phototherapy can be time-consuming, expensive, and inconvenient. Conventional home phototherapy addresses many hurdles, but has other limitations.
Assess the treatment efficacy, adherence, and satisfaction of a novel ultraviolet B home phototherapy system.
Eight patients with stable plaque psoriasis completed a multicenter, prospective, open label, interventional study using a home phototherapy device designed to improve treatment control and adherence. Matched control and study lesions were assessed on each subject. A dosing protocol based on American Academy of Dermatology guidelines for narrowband UVB phototherapy was managed by the phototherapy system. Responsiveness to the treatment was measured using the Psoriasis Severity Index (PSI) at 10 weeks versus control. Patient satisfaction was graded on a five-star Likert scale.
At 10 weeks, all patients experienced improvement in the treated lesions, with a mean improvement of 57% in PSI (P<0.0001 compared to baseline and P<0.0002 compared to the control lesions). Patient treatment adherence was 96% and treatment satisfaction was 100% five-star rated. Control lesions did not significantly change in PSI over the 10-week period (P=0.1411).
The home phototherapy system provided a safe and effective means to manage plaque psoriasis.
光疗对治疗银屑病和其他皮肤疾病有效。然而，基于诊所的光疗可能耗时、昂贵且不方便。传统的家庭光疗解决了许多障碍，但也有其他局限性。
评估一种新型紫外线B家庭光疗系统的治疗效果、依从性和满意度。
8例稳定期斑块状银屑病患者完成了一项多中心、前瞻性、开放标签的干预性研究，使用一种旨在改善治疗控制和依从性的家庭光疗设备。对每个受试者的匹配对照和研究皮损进行评估。光疗系统根据美国皮肤病学会窄带UVB光疗指南管理给药方案。在10周时使用银屑病严重程度指数（PSI）与对照相比来测量对治疗的反应性。患者满意度采用五星李克特量表进行评分。
在10周时，所有患者的治疗皮损均有改善，PSI平均改善57%（与基线相比P<0.0001，与对照皮损相比P<0.0002）。患者治疗依从性为96%，治疗满意度为100%（五星级评分）。对照皮损在10周期间PSI没有显著变化（P=0.1411）。
家庭光疗系统为治疗斑块状银屑病提供了一种安全有效的方法。
