Kritchevsky D, Weber M M, Buck C L, Klurfeld D M
Lipids. 1986 Apr;21(4):272-4. doi: 10.1007/BF02536411.
The experiments reported are part of our effort to dissociate the tumor-enhancing effects of dietary fat and high caloric intake. Rats either were fed ad libitum diets containing 4% corn oil or their calories were restricted by 40% and their diets contained 13.1% corn oil. Incidence of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors was 80% in rats fed ad libitum and 20% in those fed the calorie-restricted diets. Incidence of 1,2-dimethylhydrazine (DMH)-induced colon tumors was 100% in rats fed ad libitum and 53% in those whose caloric intake was restricted by 40%. The tumor yield (tumors per tumor-bearing rat) was significantly lower in rats on caloric restriction. In another series, rats were fed diets containing 5, 15 or 20% corn oil ad libitum or were fed calorie-restricted (by 25%) diets which provided 20 or 26.6% corn oil (therefore, the same absolute amount of fat was consumed in each of the pair-fed groups). Tumor incidence and tumor yield in the two calorie-restricted groups were similar to those seen in the rats fed 5% fat ad libitum; tumor burden (total g of tumor) was 45-65% lower in the calorie-restricted rats. The data suggest that caloric intake is a more stringent determinant of tumor growth than fat intake.
所报道的实验是我们为区分膳食脂肪和高热量摄入对肿瘤的促进作用所做努力的一部分。大鼠要么随意进食含4%玉米油的日粮，要么热量摄入受限40%，其日粮含13.1%玉米油。在随意进食的大鼠中，7,12-二甲基苯并(a)蒽（DMBA）诱导的乳腺肿瘤发生率为80%，而在热量摄入受限的大鼠中为20%。在随意进食的大鼠中，1,2-二甲基肼（DMH）诱导的结肠肿瘤发生率为100%，而热量摄入受限40%的大鼠中为53%。热量受限的大鼠肿瘤产量（每只患瘤大鼠的肿瘤数）显著更低。在另一组实验中，大鼠随意进食含5%、15%或20%玉米油的日粮，或者进食热量受限（25%）的日粮，这些日粮含20%或26.6%玉米油（因此，每对喂食组消耗的脂肪绝对量相同）。两个热量受限组的肿瘤发生率和肿瘤产量与随意进食5%脂肪的大鼠相似；热量受限大鼠的肿瘤负荷（肿瘤总克数）低45 - 65%。数据表明，热量摄入比脂肪摄入对肿瘤生长的决定作用更为严格。
