Department of Biochemistry and Biotechnology, Human Nutrition Unit, IISPV, Hospital Universitari Sant Joan de Reus, Rovira i Virgili University, 43003 Reus, Spain.
CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Nutrients. 2019 Mar 7;11(3):576. doi: 10.3390/nu11030576.
There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline ( = 282) and 1-year ( = 143) changes in the levels of fatty acids in blood cell membranes with circulating inflammatory markers in older adults at high cardiovascular risk. The data for this cross-sectional analysis was obtained from a case-control study within the PREDIMED study. Linear regression with elastic net penalty was applied to test associations between measured fatty acids and inflammatory markers. Several fatty acids were associated with interferon-γ (IFNγ) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year. Omega-6 fatty acids were consistently positively associated with pro-inflammatory IL-6 and IL-8 at baseline. Omega-3 fatty acids including C20:5n3 and C18:3n3 were negatively associated with IFN-γ at 1 year. It is interesting to note that the cis and trans forms of C16:1n7 at 1 year were oppositely associated with the inflammatory markers. C16:1n7trans was negatively associated with IFN-γ, IL-6, IL-8, IL-10, and IL-1b, whereas C16:1n7cis was positively associated with IL-1b. This study adds to the growing body of evidence suggesting potential differences in inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes.
来自血液细胞膜中脂肪酸的炎症或抗炎特性的流行病学研究证据有限。因此，本研究在高心血管风险的老年人中，检查了血液细胞膜中脂肪酸基线（= 282）和 1 年（= 143）水平变化与循环炎症标志物之间的关联。这项横断面分析的数据来自 PREDIMED 研究中的病例对照研究。应用弹性网络惩罚的线性回归检验了所测脂肪酸与炎症标志物之间的关联。几种脂肪酸与干扰素-γ（IFNγ）和白细胞介素（ILs）IL-6、IL-8 和 IL-10 相关，基线时有相关性，1 年后也与 IL-1b 相关。在基线时，ω-6 脂肪酸与促炎 IL-6 和 IL-8 呈一致的正相关。包括 C20:5n3 和 C18:3n3 在内的 ω-3 脂肪酸与 1 年时的 IFNγ呈负相关。有趣的是，C16:1n7 的顺式和反式在 1 年时与炎症标志物呈相反的关联。C16:1n7trans 与 IFNγ、IL-6、IL-8、IL-10 和 IL-1b 呈负相关，而 C16:1n7cis 与 IL-1b 呈正相关。本研究增加了越来越多的证据，表明血液细胞膜中脂肪酸的炎症或抗炎特性可能存在差异。
