University of Eastern Finland, Institute of Public Health and Clinical Nutrition, P.O. Box 1627, 70211, Kuopio, Finland.
Eur J Clin Nutr. 2018 Mar;72(3):342-348. doi: 10.1038/s41430-017-0009-6. Epub 2017 Nov 6.
BACKGROUND/OBJECTIVES: There are concerns that high intake of n-6 polyunsaturated fatty acids (PUFA) may promote inflammation, because the end-product of n-6 PUFA metabolism, arachidonic acid, is a precursor for pro-inflammatory eicosanoids. Our aim was to investigate cross-sectional associations of the serum n-6 PUFAs, objective biomarkers for exposure, with serum high-sensitivity C-reactive protein (CRP), a key inflammation marker.
SUBJECTS/METHODS: The study included 1287 generally healthy men aged 42-60 years from the population-based Kuopio Ischaemic Heart Disease Risk Factor Study, examined in 1984-1989. ANCOVA and logistic regression were used for analyses.
In the multivariable-adjusted analyses, both serum total n-6 PUFA and linoleic acid, the predominant n-6 PUFA, were associated with lower CRP. The mean CRP concentrations in quartiles of linoleic acid were 1.86, 1.51, 1.53, and 1.37 mg/L (P-trend = 0.001). The odds ratio for elevated CRP (>3 mg/L) in the highest vs. the lowest quartile was 0.47 (95% confidence interval (CI) 0.25-0.87, P-trend = 0.01). Arachidonic acid or the mainly endogenously produced n-6 PUFAs, gamma-linolenic acid and dihomo-gamma-linolenic acid, were not associated with higher CRP, either. Age, body mass index, or serum long-chain n-3 PUFA concentration did not modify the associations (P-interactions > 0.14).
Serum n-6 PUFAs were not associated with increased inflammation in men. In contrast, the main n-6 PUFA linoleic acid had a strong inverse association with the key inflammation marker, CRP.
背景/目的：人们担心高摄入 n-6 多不饱和脂肪酸（PUFA）可能会促进炎症，因为 n-6 PUFA 代谢的终产物，花生四烯酸，是促炎类二十烷酸的前体。我们的目的是研究血清 n-6 PUFA，暴露的客观生物标志物，与血清高敏 C 反应蛋白（CRP）之间的横断面关联，CRP 是关键的炎症标志物。
对象/方法：该研究纳入了 1984-1989 年来自基于人群的库奥皮奥缺血性心脏病危险因素研究的 1287 名一般健康的 42-60 岁男性。采用协方差分析和 logistic 回归进行分析。
在多变量调整分析中，血清总 n-6 PUFA 和亚油酸，主要的 n-6 PUFA，与 CRP 降低相关。亚油酸四分位血清 CRP 浓度分别为 1.86、1.51、1.53 和 1.37mg/L（P 趋势=0.001）。最高与最低四分位相比，CRP 升高（>3mg/L）的比值比为 0.47（95%置信区间 0.25-0.87，P 趋势=0.01）。花生四烯酸或主要内源性产生的 n-6 PUFA，γ-亚麻酸和二高-γ-亚麻酸，与 CRP 升高也没有关联。年龄、体重指数或血清长链 n-3 PUFA 浓度没有改变这种关联（P 交互作用>0.14）。
血清 n-6 PUFA 与男性炎症增加无关。相比之下，主要的 n-6 PUFA 亚油酸与关键炎症标志物 CRP 呈强负相关。
