Di Francesco Simona, Robuffo Iole, Caruso Marika, Giambuzzi Giulia, Ferri Deborah, Militello Andrea, Toniato Elena
Department of Medical and Oral Sciences and Biotechnologies, G. D'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy.
Department of Urological, Biomedical and Translational Sciences, Federiciana University, 87100 Cosenza, Italy.
Medicina (Kaunas). 2019 Mar 7;55(3):62. doi: 10.3390/medicina55030062.
: Epidemiological studies suggest a possible relationship between metabolic alterations, cardiovascular disease and aggressive prostate cancer, however, no clear consensus has been reached. : The aim of the study was to analyze the recent literature and summarize our experience on the association between metabolic disorders, aggressive hormone-naïve prostate cancer and cardiovascular disease. : We identified relevant papers by searching in electronic databases such as Scopus, Life Science Journals, and Index Medicus/Medline. Moreover, we showed our experience on the reciprocal relationship between metabolic alterations and aggressive prostate cancer, without the influence of hormone therapy, as well the role of coronary and carotid vasculopathy in advanced prostate carcinoma. : Prostate cancer cells have an altered metabolic homeostatic control linked to an increased aggressivity and cancer mortality. The absence of discrimination of risk factors as obesity, systemic arterial hypertension, diabetes mellitus, dyslipidemia and inaccurate selection of vascular diseases as coronary and carotid damage at initial diagnosis of prostate cancer could explain the opposite results in the literature. Systemic inflammation and oxidative stress associated with metabolic alterations and cardiovascular disease can also contribute to prostate cancer progression and increased tumor aggressivity. : Metabolic alterations and cardiovascular disease influence aggressive and metastatic prostate cancer. Therefore, a careful evaluation of obesity, diabetes mellitus, dyslipidemia, systemic arterial hypertension, together with a careful evaluation of cardiovascular status, in particular coronary and carotid vascular disease, should be carried out after an initial diagnosis of prostatic carcinoma.
流行病学研究表明代谢改变、心血管疾病与侵袭性前列腺癌之间可能存在关联，然而，尚未达成明确共识。本研究旨在分析近期文献，并总结我们在代谢紊乱、激素初治侵袭性前列腺癌与心血管疾病之间关联方面的经验。我们通过在Scopus、生命科学期刊和医学索引/医学期刊数据库等电子数据库中检索来确定相关论文。此外，我们展示了在无激素治疗影响的情况下，代谢改变与侵袭性前列腺癌之间的相互关系的经验，以及冠状动脉和颈动脉血管病变在晚期前列腺癌中的作用。前列腺癌细胞的代谢稳态控制发生改变，这与侵袭性增加和癌症死亡率升高有关。在前列腺癌初诊时，对肥胖、系统性动脉高血压、糖尿病、血脂异常等危险因素缺乏区分，以及对冠状动脉和颈动脉损伤等血管疾病的选择不准确，可能解释了文献中出现的相反结果。与代谢改变和心血管疾病相关的全身炎症和氧化应激也可能促进前列腺癌进展并增加肿瘤侵袭性。代谢改变和心血管疾病会影响侵袭性和转移性前列腺癌。因此，在前列腺癌初诊后，应仔细评估肥胖、糖尿病、血脂异常、系统性动脉高血压，同时仔细评估心血管状况，特别是冠状动脉和颈动脉血管疾病。
