腔内和间质近距离放疗联合治疗局部晚期宫颈癌的技术：单中心经验的初步结果。
A hybrid technique of intracavitary and interstitial brachytherapy for locally advanced cervical cancer: initial outcomes of a single-institute experience.
机构信息
Department of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Department of Radiotherapy and Oncology, Goethe-University Frankfurt, Frankfurt am Main, Germany.
出版信息
BMC Cancer. 2019 Mar 12;19(1):221. doi: 10.1186/s12885-019-5430-x.
BACKGROUND
Locally advanced uterine cervical cancer (LAUCC) with lateral tumor extension may not always be covered adequately by conventional intracavitary brachytherapy (ICBT). Hybrid intracavitary and interstitial brachytherapy (HBT) seems to be an effective alternative by improving anatomy-oriented dose optimisation. The purpose of this study was to report initial clinical result for LAUCC treated by HBT.
METHODS
Between January 2012 and November 2015, 42 patients with LAUCC (T1b2-4a) were treated with primary radiation therapy including HBT. Patients with distant metastasis other than para-aortic lymph node spread were excluded from this study. A retrospective analysis was performed for toxicity evaluation and oncological outcome calculation.
RESULTS
Median follow-up was 23.2 months (range 13.2-71.4). Two-year overall survival, progression free survival, and local control rate were 81.6, 54.4, and 80.2%, respectively. Seven patients experienced local recurrence (16.6%). Of those, five were confined to the uterus and two at the parametria. Late adverse events ≥ grade 3 were seen in 3 patients.
CONCLUSIONS
HBT can generate favorable local control in tumors which cannot be adequately covered by ICBT.
背景
局部晚期宫颈癌（LAUCC）伴侧方肿瘤延伸，常规腔内近距离放疗（ICBT）可能无法充分覆盖。腔内和间质近距离放疗联合（HBT）似乎是一种有效的替代方法，通过改善基于解剖的剂量优化来提高疗效。本研究旨在报道 HBT 治疗 LAUCC 的初步临床结果。
方法
2012 年 1 月至 2015 年 11 月，42 例 LAUCC（T1b2-4a）患者接受了包括 HBT 在内的根治性放疗。本研究排除了远处转移（除了腹主动脉旁淋巴结转移）的患者。对毒性评估和肿瘤学结果计算进行回顾性分析。
结果
中位随访时间为 23.2 个月（范围 13.2-71.4）。2 年总生存率、无进展生存率和局部控制率分别为 81.6%、54.4%和 80.2%。7 例患者出现局部复发（16.6%）。其中，5 例局限于子宫，2 例局限于宫旁。3 例出现≥3 级晚期不良事件。
结论
HBT 可使无法通过 ICBT 充分覆盖的肿瘤获得良好的局部控制。
Zotero 插件