Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.
Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Jpn J Radiol. 2024 Jan;42(1):96-101. doi: 10.1007/s11604-023-01481-4. Epub 2023 Aug 17.
This study evaluated the efficacy and safety of transvaginal approach combined intracavitary and interstitial brachytherapy (IC/IS BT) assisted by transrectal ultrasound (TRUS) for treatment of locally advanced cervical cancer (LACC).
A total of 30 patients of LACC treated with external beam radiotherapy and IC/IS BT via transvaginal approach assisted by transrectal ultrasound were observed retrospectively. The 2-year local control (LC), progression-free survival (PFS), and overall survival (OS) were analyzed using the Kaplan-Meier method. Late adverse events were also evaluated to assess the safety of IC/IS BT.
The median follow-up period was 22 months. The 2-year LC, PFS, and OS were 90%, 61%, and 82%, respectively. We observed no critical complications related to the IC/IS BT technique. Late adverse events of grade 3 or more included one case of grade 4 colon perforation.
Our patient series demonstrated that radiotherapy combined with transvaginal approach, TRUS-assisted IC/IS BT achieves favorable local control and safety for LACC.
本研究评估经阴道途径联合腔内和间质近距离放疗（IC/IS BT）辅助经直肠超声（TRUS）治疗局部晚期宫颈癌（LACC）的疗效和安全性。
回顾性观察 30 例接受外照射放疗和经阴道途径 IC/IS BT 的 LACC 患者。采用 Kaplan-Meier 法分析 2 年局部控制率（LC）、无进展生存率（PFS）和总生存率（OS）。还评估了晚期不良事件，以评估 IC/IS BT 的安全性。
中位随访时间为 22 个月。2 年 LC、PFS 和 OS 分别为 90%、61%和 82%。我们未观察到与 IC/IS BT 技术相关的严重并发症。3 级或更高级别的晚期不良事件包括 1 例 4 级结肠穿孔。
我们的患者系列表明，放疗联合经阴道途径、TRUS 辅助 IC/IS BT 治疗 LACC 可获得良好的局部控制和安全性。
