Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.
Br J Cancer. 2019 Apr;120(8):848-854. doi: 10.1038/s41416-019-0426-5. Epub 2019 Mar 14.
Individuals with a family history of cancer may be at increased risk of pancreatic cancer. Ashkenazi Jewish (AJ) individuals carry increased risk for pancreatic cancer and other cancer types.
We examined the association between family history of cancer, AJ heritage, and incident pancreatic cancer in 49 410 male participants of the prospective Health Professionals Follow-up Study. Hazard ratios (HRs) were estimated using multivariable-adjusted Cox proportional hazards models.
During 1.1 million person-years (1986-2016), 452 participants developed pancreatic cancer. Increased risk of pancreatic cancer was observed in individuals with a family history of pancreatic (HR, 2.79; 95% confidence interval [CI], 1.28-6.07) or breast cancer (HR, 1.40; 95% CI, 1.01-1.94). There was a trend towards higher risk of pancreatic cancer in relation to a family history of colorectal cancer (HR, 1.21; 95% CI, 0.95-1.55) or AJ heritage (HR, 1.29; 95% CI, 0.94-1.77). The risk was highly elevated among AJ men with a family history of breast or colorectal cancer (HR, 2.61 [95% CI, 1.41-4.82] and 1.92 [95% CI, 1.05-3.49], respectively).
Family history of pancreatic cancer was associated with increased risk of this malignancy. Family history of breast or colorectal cancer was associated with the increased risk among AJ men.
有癌症家族史的个体患胰腺癌的风险可能会增加。阿什肯纳兹犹太人（AJ）个体患胰腺癌和其他癌症类型的风险增加。
我们在前瞻性健康专业人员随访研究的 49410 名男性参与者中，研究了癌症家族史、AJ 血统与胰腺癌发病之间的关联。使用多变量调整的 Cox 比例风险模型估计风险比（HR）。
在 110 万人年（1986-2016 年）期间，有 452 名参与者患上了胰腺癌。有胰腺癌家族史（HR，2.79；95%置信区间[CI]，1.28-6.07）或乳腺癌家族史（HR，1.40；95%CI，1.01-1.94）的个体患胰腺癌的风险增加。与结直肠癌（HR，1.21；95%CI，0.95-1.55）或 AJ 血统（HR，1.29；95%CI，0.94-1.77）家族史相关，胰腺癌的发病风险呈上升趋势。具有乳腺癌或结直肠癌家族史的 AJ 男性的风险显著升高（HR，2.61[95%CI，1.41-4.82]和 1.92[95%CI，1.05-3.49]）。
胰腺癌家族史与这种恶性肿瘤的风险增加相关。乳腺癌或结直肠癌家族史与 AJ 男性的风险增加相关。
