Wang Yong, Zhou Shiying, Fan Kefeng, Jiang Chen
Department of Obstetrics, Jinan Maternity and Child Care Hospital, Jinan, Shandong 250002, P.R. China.
Department of Gynecology, Jinan Maternity and Child Care Hospital, Jinan, Shandong 250002, P.R. China.
Oncol Lett. 2019 Mar;17(3):3066-3070. doi: 10.3892/ol.2019.10002. Epub 2019 Feb 1.
Oncogenic microRNA-21 (miR-21/miRNA-21) is a stable inhibitor of gene expression that is often upregulated in cervical cancer, a disease that affects the health of women and tends to transform and spread. Previous studies investigating miR-21 in biopsies and cells from cervical cancer patients have identified that miR-21 binds target mRNAs in signaling pathways or long non-coding RNAs (lncRNA). Furthermore, studies have elucidated the molecular mechanisms of two tumor necrosis factor α (TNF-α) signaling pathways that promote cell proliferation and inhibit cell apoptosis. miR-21 inhibits the TNF receptor 1 (TNFR1) signaling pathway and activates the TNFR2 signaling pathway. Moreover, miR-21 enhances cervical cancer cell proliferation by influencing the protein kinase B/mammalian target of rapamycin and RAS p21 protein activator 1 signaling pathways. The present review discusses the evidence that miR-21 may impact cervical cancer through inhibiting apoptosis and enhancing proliferation, and may therefore be a target for clinical intervention.
致癌性微小RNA-21（miR-21/miRNA-21）是一种稳定的基因表达抑制剂，在宫颈癌中常上调。宫颈癌是一种影响女性健康且易于转移和扩散的疾病。先前对宫颈癌患者活检组织和细胞中miR-21的研究已确定，miR-21与信号通路中的靶标mRNA或长链非编码RNA（lncRNA）结合。此外，研究还阐明了两条促进细胞增殖并抑制细胞凋亡的肿瘤坏死因子α（TNF-α）信号通路的分子机制。miR-21抑制肿瘤坏死因子受体1（TNFR1）信号通路并激活TNFR2信号通路。此外，miR-21通过影响蛋白激酶B/雷帕霉素哺乳动物靶标和RAS p21蛋白激活剂1信号通路来增强宫颈癌细胞增殖。本综述讨论了miR-21可能通过抑制凋亡和增强增殖而影响宫颈癌的证据，因此可能成为临床干预的靶点。
