Wang Fei, Zhang Xue, Wang Huihui, Liu Yi
Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.
Oncol Lett. 2019 Mar;17(3):3392-3398. doi: 10.3892/ol.2019.9964. Epub 2019 Jan 23.
The effects of dezocine and sufentanyl on the activity of natural killer (NK), CD4 and CD8 cells in patients with breast cancer undergoing postoperative analgesia after radical mastectomy were compared. The clinical data of 76 female patients undergoing radical mastectomy in the Fudan University Shanghai Cancer Center from January 2015 to October 2017 were analyzed retrospectively. Forty-two patients treated with dezocine were group D and 34 patients with sufentanyl were group S. Visual analogue scale (VAS) was used to evaluate the analgesic effect at 3, 12, 24, 48 h after surgery. There was no significant difference in VAS score, NK cells, CD4 cells, and CD8 cell vitality at 3 h postoperatively between the two groups (P>0.05), and VAS score at 12, 24 and 48 h postoperatively in the S group was significantly lower than that in group D (P<0.05). The activity of NK cells and CD4 cells at 3, 12, 24 and 48 h after surgery in group D was significantly higher than that in group S, and the difference was statistically significant (P<0.05). The activity of CD8 cells at 3, 12, 24 and 48 h after surgery in group D was significantly lower than that in group S, and the difference was statistically significant (P<0.05). The analgesic effect of dezocine was slightly worse than that of sufentanyl, but it was more beneficial to the recovery of early postoperative immune function.
比较了地佐辛和舒芬太尼对乳腺癌根治术后患者进行术后镇痛时自然杀伤（NK）细胞、CD4和CD8细胞活性的影响。回顾性分析了2015年1月至2017年10月在复旦大学附属肿瘤医院接受乳腺癌根治术的76例女性患者的临床资料。42例接受地佐辛治疗的患者为D组，34例接受舒芬太尼治疗的患者为S组。采用视觉模拟评分法（VAS）评估术后3、12、24、48 h的镇痛效果。两组术后3 h时VAS评分、NK细胞、CD4细胞及CD8细胞活力比较，差异无统计学意义（P>0.05），S组术后12、24、48 h时VAS评分显著低于D组（P<0.05）。D组术后3、12、24、48 h时NK细胞及CD4细胞活性显著高于S组，差异有统计学意义（P<0.05）。D组术后3、12、24、48 h时CD8细胞活性显著低于S组，差异有统计学意义（P<0.05）。地佐辛的镇痛效果略逊于舒芬太尼，但更有利于术后早期免疫功能的恢复。
