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登革热和登革出血热中 mRNA 和长链非编码 RNA 表达的全基因组分析。

Genome-wide profiling of mRNA and lncRNA expression in dengue fever and dengue hemorrhagic fever.

机构信息

Department of Quality Control Huadu Hospital of Southern Medical University & Guangzhou Huadu District People's Hospital China.

Department of Medicine Huadu Hospital of Southern Medical University & Guangzhou Huadu District People's Hospital China.

出版信息

FEBS Open Bio. 2019 Feb 2;9(3):468-477. doi: 10.1002/2211-5463.12576. eCollection 2019 Mar.

DOI:10.1002/2211-5463.12576
PMID:30868055
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6396354/
Abstract

Dengue fever (DF) and dengue hemorrhagic fever (DHF) are recurrent diseases that are widespread in the tropics. Here, we identified candidate genes associated with these diseases by performing integrated analyses of DF (GSE51808) and DHF (GSE18090) microarray datasets in the Gene Expression Omnibus (GEO). In all, we identified 7635 differentially expressed genes (DEGs) in DF and 8147 DEGs in DHF as compared to healthy controls ( < 0.05). In addition, we discovered 215 differentially expressed long non-coding RNAs (DElncRNAs) in DF and 225 DElncRNAs in DHF. There were 1256 common DEGs and eight common DElncRNAs in DHF DF, DHF normal control, and DF normal control groups. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that signal transduction (false discovery rate = 8.33E-10), 'toxoplasmosis', and 'protein processing in endoplasmic reticulum' were significantly enriched pathways for common DEGs. We conclude that the ,, and genes may play crucial roles in DF and DHF, and suggest that our findings may facilitate the identification of biomarkers and the development of new drug design strategies for DF and DHF treatment.

摘要

登革热（DF）和登革出血热（DHF）是在热带地区广泛流行的复发性疾病。在这里，我们通过对基因表达综合分析，在 GEO 数据库中鉴定了与这些疾病相关的候选基因。在所有，我们发现了 7635 个差异表达基因（DEGs）在 DF 和 8147 个 DEGs 在 DHF 与健康对照组相比（<0.05）。此外，我们发现 215 个差异表达的长非编码 RNA（DElncRNAs）在 DF 和 225 个 DElncRNAs 在 DHF。有 1256 个共同的 DEGs 和八个共同的 DElncRNAs 在 DHF-DF，DHF-正常对照组和 DF-正常对照组。基因本体论（GO）和京都基因与基因组百科全书（KEGG）富集分析表明，信号转导（错误发现率= 8.33E-10），“弓形体病”和“内质网蛋白加工”是共同 DEGs 显著富集途径。我们得出结论，和基因可能在 DF 和 DHF 中发挥关键作用，并表明我们的研究结果可能有助于鉴定生物标志物和开发新的药物设计策略，用于 DF 和 DHF 的治疗。

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