School of Sport Science Beijing Sport University China.
Faculty of Health, Engineering and Sciences University of Southern Queensland Toowoomba Australia.
FEBS Open Bio. 2019 Jan 23;9(3):498-509. doi: 10.1002/2211-5463.12587. eCollection 2019 Mar.
High altitude hypoxia adaptation can improve glucose tolerance in people with metabolic syndrome and type 2 diabetes (T2D). Apelin is an endogenous ligand of the G protein-coupled receptor APJ and has possible roles in energy metabolism. Apelin-null mice have been reported to exhibit impaired insulin sensitivity, which can be reversed by supplementation of exogenous apelin. Here, we examined the effects of 4 weeks' intermittent hypoxia exposure on physiological and biochemical variables in apelin knockout (KO) mice. Apelin KO mice exhibited decreased expression of substrate metabolism-associated genes/proteins, impaired glucose tolerance, and reduced exercise capacity compared to wild-type mice, and all of these effects were rescued by hypoxia. These findings suggest that hypoxia intervention may possibly be able to alleviate metabolic conditions caused by genetic defects.
高原低氧适应可以改善代谢综合征和 2 型糖尿病（T2D）患者的葡萄糖耐量。Apelin 是 G 蛋白偶联受体 APJ 的内源性配体，在能量代谢中可能发挥作用。已有报道称 Apelin 敲除（KO）小鼠表现出胰岛素敏感性受损，外源性 Apelin 的补充可以逆转这种情况。在这里，我们研究了 4 周间歇性低氧暴露对 Apelin KO 小鼠生理和生化变量的影响。与野生型小鼠相比，Apelin KO 小鼠表现出与底物代谢相关的基因/蛋白表达减少、葡萄糖耐量受损和运动能力降低，而这些影响都可以通过低氧来挽救。这些发现表明，低氧干预可能能够缓解由遗传缺陷引起的代谢状况。
