Efthimiou J, McLelland J, Betteridge D J
Postgrad Med J. 1986 Apr;62(726):285-7. doi: 10.1136/pgmj.62.726.285.
Two brothers with Fabry's disease presenting with palpitations were found to have intermittent supraventricular tachycardias. Their electrocardiograms, when symptom-free, revealed short PR intervals consistent with ventricular pre-excitation. Treatment of one of the brothers with verapamil resulted in improvement of the palpitations and reduction in frequency of the tachycardia. Recurrent supraventricular tachycardia associated with ventricular pre-excitation has not previously been described in Fabry's disease. Evidence suggests that this complication may be due to glycolipid deposition in the conducting system around the atrioventricular node.
两名患有法布里病且出现心悸症状的兄弟被发现患有间歇性室上性心动过速。他们无症状时的心电图显示PR间期缩短，符合心室预激表现。其中一名兄弟接受维拉帕米治疗后，心悸症状改善，心动过速发作频率降低。法布里病患者中此前尚未有与心室预激相关的复发性室上性心动过速的报道。有证据表明，这种并发症可能是由于房室结周围传导系统中的糖脂沉积所致。
