Wang Lu, Qi Chaorong, Guo Tianzuo, Jiang Huanfeng
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering , South China University of Technology , Guangzhou 510640 , P.R. China.
State Key Laboratory of Luminescent Materials and Devices , South China University of Technology , Guangzhou 510640 , P.R. China.
Org Lett. 2019 Apr 5;21(7):2223-2226. doi: 10.1021/acs.orglett.9b00518. Epub 2019 Mar 14.
A copper-catalyzed four-component formal oxyaminalization of alkenes with Togni's reagent and amines using molecular oxygen as both the oxidant and oxygen source has been developed for the first time, offering a straightforward and efficient method for the synthesis of a range of structurally diverse α-oxoketene aminals. The use of cheap copper catalyst and readily available substrates, excellent functional group tolerance, broad substrate scope, mild conditions, and simple procedure are the attractive features of the strategy.
首次开发了一种铜催化的烯烃与托格尼试剂和胺的四组分正式氧胺化反应，使用分子氧作为氧化剂和氧源，为一系列结构多样的α-氧代烯酮缩胺的合成提供了一种直接有效的方法。使用廉价的铜催化剂和易于获得的底物、优异的官能团耐受性、广泛的底物范围、温和的条件以及简单的操作步骤是该策略的吸引人之处。
