急性寒冷暴露期间人体血液中的锌代谢

Zinc metabolism in human blood during acute exposure to cold.

作者信息

Ohno H, Yahata T, Yamashita K, Doi R, Taniguchi N, Kuroshima A

出版信息

Res Commun Chem Pathol Pharmacol. 1986 May;52(2):251-64.

Abstract

Effects of acute exposure to cold (10 degrees C for 60 min) on the concentrations of zinc and related proteins in red blood cells and in plasma were studied on seven male students. Lower concentrations of total zinc and of zinc derived from carbonic anhydrase I (CA-I) in red blood cells were found during cold exposure and 15 min after cold exposure, whereas no significant changes occurred in the concentration of zinc derived from carbonic anhydrase II (CA-II) or Cu2Zn2 superoxide dismutase (SOD1). The decrease in total zinc concentration in red blood cells was mostly due to that in CA-I concentration. On the other hand, there were not any changes in total zinc, albumin-bound zinc, and alpha 2-macroglobulin-bound zinc concentrations in plasma during the experimental period. These results, together with the marked hemoconcentration during cold exposure, suggest that cold stress induces an efflux of zinc from plasma.

摘要

对七名男学生研究了急性暴露于寒冷环境（10摄氏度，60分钟）对红细胞和血浆中锌及相关蛋白质浓度的影响。在冷暴露期间及冷暴露后15分钟，发现红细胞中总锌以及源自碳酸酐酶I（CA-I）的锌浓度降低，而源自碳酸酐酶II（CA-II）或铜锌超氧化物歧化酶（SOD1）的锌浓度未发生显著变化。红细胞中总锌浓度的降低主要归因于CA-I浓度的降低。另一方面，在实验期间，血浆中的总锌、白蛋白结合锌和α2-巨球蛋白结合锌浓度没有任何变化。这些结果，连同冷暴露期间明显的血液浓缩，表明冷应激诱导锌从血浆中流出。