Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China.
Org Biomol Chem. 2019 Mar 27;17(13):3424-3432. doi: 10.1039/c9ob00377k.
A novel strategy for constructing sulfur containing bis-S-heterocyclic compounds from oxime esters/vinyl azide, phenylacetylene/aldehydes and elemental sulfur (S8) has been developed. These transformations show good functional group tolerance. Various bis-S-heterocyclic products were efficiently synthesized from easily prepared or widely commercially available starting materials. In this protocol, S8 successfully served as a two-sulfur atom donor for thiophene and thiazole rings, respectively.
一种从肟酯/乙烯基叠氮化物、苯乙炔/醛和单质硫（S8）构建含硫双杂环化合物的新策略已经被开发出来。这些转化反应具有良好的官能团容忍性。各种双杂环产物可以从易于制备或广泛市售的起始原料高效合成。在本方案中，S8 成功地分别作为噻吩和噻唑环的两个硫原子供体。
