Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Division of Urology, Faculty of Medicine, Irbid, Jordan.
Neurourol Urodyn. 2019 Apr;38(4):1160-1167. doi: 10.1002/nau.23975. Epub 2019 Mar 14.
Overactive bladder (OAB) is a prevalent syndrome that is associated with multiple urinary tract symptoms and could affect the patient's quality of life and well-being. Vitamin D is shown to be linked to OAB syndrome, which exacerbated by stress conditions. This study evaluated the relationship between vitamin D status, daily calcium intake and OAB, and the associated psychological symptoms.
The study included 55 patients with OAB and 129 healthy controls. Psychological symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS). Serum vitamin D was measured. Patients with OAB with low vitamin D level received orally vitamin D supplementation. Urinary symptoms, psychological symptoms, and quality of life were evaluated before and after vitamin D supplementation plus dairy products.
Vitamin D deficiency was more prevalent in cases (80%) vs controls (34.9%). Depression (43.7% vs 20.2%) and anxiety (52.8% vs 10.9%) scores (HADS, ≥8) were also more frequent in cases vs controls, respectively. Some 85.5% of the patients' group had musculoskeletal pain vs 0.0% for the control. Depression was negatively correlated with daily calcium intake and positively with anxiety. Logistic regression analysis revealed that age, vitamin D, and anxiety scores were significant predictors of OAB. Vitamin D supplements with increased calcium intake had significant improvement in urinary symptoms, psychological distress, and quality of life.
Vitamin D supplements and improved calcium intake may improve urinary and psychological symptoms and quality of life among patients with OAB syndrome. Assessment for vitamin D status in patients with OAB may be warranted.
膀胱过度活动症（OAB）是一种常见的综合征，与多种尿路症状相关，并可能影响患者的生活质量和幸福感。维生素 D 与 OAB 综合征有关，且与应激状态有关。本研究评估了维生素 D 状态、每日钙摄入量与 OAB 之间的关系，以及与 OAB 相关的心理症状。
该研究纳入了 55 例 OAB 患者和 129 名健康对照者。使用医院焦虑抑郁量表（HADS）评估心理症状。检测血清维生素 D。维生素 D 水平低的 OAB 患者接受口服维生素 D 补充剂治疗。在接受维生素 D 补充剂和乳制品治疗前后，评估患者的尿症状、心理症状和生活质量。
病例组（80%）的维生素 D 缺乏症发生率高于对照组（34.9%）。病例组的抑郁（43.7% vs. 20.2%）和焦虑（52.8% vs. 10.9%）评分（HADS，≥8）也高于对照组。85.5%的患者组有肌肉骨骼疼痛，而对照组为 0.0%。抑郁与每日钙摄入量呈负相关，与焦虑呈正相关。Logistic 回归分析显示，年龄、维生素 D 和焦虑评分是 OAB 的显著预测因素。补充维生素 D 和增加钙摄入可显著改善 OAB 患者的尿症状、心理困扰和生活质量。
维生素 D 补充剂和增加钙摄入可能改善 OAB 患者的尿症状和心理症状，并提高其生活质量。在 OAB 患者中评估维生素 D 状态可能是必要的。
