Gong Hongyang, Zhao Weimin, Choi Seok, Huang Shaoqun
Department of Oncology Surgery, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou City, Fujian Province, China.
Department of Physiology, College of Medicine, Chosun University, Gwangju, Korea.
J Health Popul Nutr. 2025 Apr 3;44(1):106. doi: 10.1186/s41043-025-00846-x.
This study aimed to assess the relationship between magnesium depletion score (MDS) and overactive bladder (OAB) prevalence.
This study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. Multivariate logistic regression was employed to investigate the association between MDS and OAB. Restricted cubic spline (RCS) analysis explored the linear or non-linear relationship between MDS and OAB. Interaction analyses were conducted on subgroups to validate the findings.
There was a significant positive association between MDS and OAB. After adjusting for covariates, with each unit increase in MDS, there was an 11% increase in the prevalence of infertility (P < 0.001). In addition, the incidence of OAB was significantly increased in the higher MDS group compared to the low MDS group (MDS = 0) (P for trend < 0.001). The dose-response curve indicated a linear association between MDS and OAB, with higher MDS associated with higher OAB.
The results of this study show a strong positive correlation between MDS and the prevalence of OAB. These findings suggest that monitoring and managing magnesium status may be a potential strategy for reducing the risk of OAB.
本研究旨在评估镁缺乏评分（MDS）与膀胱过度活动症（OAB）患病率之间的关系。
本研究利用了2005年至2018年美国国家健康与营养检查调查（NHANES）的数据。采用多因素逻辑回归分析来研究MDS与OAB之间的关联。使用受限立方样条（RCS）分析来探索MDS与OAB之间的线性或非线性关系。对亚组进行交互分析以验证研究结果。
MDS与OAB之间存在显著的正相关。在调整协变量后，MDS每增加一个单位，不育症患病率增加11%（P < 0.001）。此外，与低MDS组（MDS = 0）相比，高MDS组的OAB发病率显著增加（趋势P < 0.001）。剂量反应曲线表明MDS与OAB之间存在线性关联，MDS越高，OAB越高。
本研究结果表明MDS与OAB患病率之间存在强正相关。这些发现表明，监测和管理镁状态可能是降低OAB风险的潜在策略。
