Oregon National Primate Research Center/OHSU.
Iowa State University.
J Res Adolesc. 2019 Mar;29(1):54-79. doi: 10.1111/jora.12385.
The adolescent transition begins with the onset of puberty which, upstream in the brain, is initiated by the gonadotropin-releasing hormone (GnRH) pulse generator that activates the release of peripheral sex hormones. Substantial research in human and animal models has revealed a myriad of cellular networks and heritable genes that control the GnRH pulse generator allowing the individual to begin the process of reproductive competence and sexual maturation. Here, we review the latest knowledge in neuroendocrine pubertal research with emphasis on genetic and epigenetic mechanisms underlying the pubertal transition.
青春期过渡始于青春期的开始，在大脑上游，由促性腺激素释放激素 (GnRH) 脉冲发生器启动，该发生器激活外周性激素的释放。在人类和动物模型中的大量研究揭示了控制 GnRH 脉冲发生器的众多细胞网络和可遗传基因，使个体能够开始生殖能力和性成熟的过程。在这里，我们回顾了神经内分泌青春期研究的最新知识，重点介绍了青春期过渡的遗传和表观遗传机制。
