[Rhodopsin regeneration: role of interaction between the photoreceptors and pigment epithelium cells].

Regeneration of rhodopsin has been studied in the eyecup, isolated retina and retinal homogenate of frog Rana temporaia as well as in the eyecup and isolated retina of fish-flounder Limanda aspera (Pallas). Rhodopsin has been found to regenerate only in the eyecup of frog, while isorhodopsin appeared to be the final product in the frog retinal homogenate. Decrease in rhodopsin regeneration level has been resulted from addition of inhibitors--theophyllin (2.10-2 M), papaverine (10-4--10-3 M) and strophantin (2.10-4 M) To the eyecup preparations (60, 20, 23%, consequently). A conclusion is made that structural connection between pigment epithelium cells and photoreceptors is necessary to provide regeneration of native rhodopsin.