细胞免疫疗法革命：为精准治疗武装免疫系统。
The Cellular Immunotherapy Revolution: Arming the Immune System for Precision Therapy.
机构信息
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA; Parker Institute for Cancer Immunotherapy (PICI), University of California Los Angeles and California Institute of Technology, Pasadena, CA, USA.
出版信息
Trends Immunol. 2019 Apr;40(4):292-309. doi: 10.1016/j.it.2019.02.002. Epub 2019 Mar 11.
Immunotherapy treatments harnessing the patient's immune system herald a new era of personalized medicine, offering hope for curative responses in patients with serious illnesses. Cell-mediated immunity can eliminate cancer cells and provide durable remissions. This often relies on repurposing cytotoxic T cell activity through modified T cell receptors or chimeric antigen receptors. Furthermore, synthetic biology has expanded the cell engineering toolkit to provide immune cells with more functionality, including disease targeting, potency, and safety. We focus on T cell-based immunotherapy, highlighting discoveries of genetic engineering and therapeutic use. We also examine emerging paths that could be undertaken to improve this novel class of drugs, and discuss the challenges of toxicities as well as other limitations of cellular immunotherapy.
免疫疗法利用患者的免疫系统，开创了个性化医疗的新时代，为患有严重疾病的患者带来了治愈的希望。细胞介导的免疫可以消除癌细胞并提供持久的缓解。这通常依赖于通过修饰的 T 细胞受体或嵌合抗原受体重新利用细胞毒性 T 细胞的活性。此外，合成生物学扩展了细胞工程工具包，为免疫细胞提供了更多的功能，包括疾病靶向、效力和安全性。我们专注于基于 T 细胞的免疫疗法，重点介绍基因工程和治疗用途的发现。我们还研究了可以改善这种新型药物的新兴途径，并讨论了毒性以及细胞免疫疗法的其他限制等挑战。
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