Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Exp Cell Res. 2019 May 15;378(2):232-237. doi: 10.1016/j.yexcr.2019.03.016. Epub 2019 Mar 12.
Animal cells exhibit a wide range of shapes that reflect their diverse functions. Cell shape is determined by a balance between internal and external forces and therefore involves the cytoskeleton and its associated adhesion structures. Cell shape dynamics during development and homeostasis are tightly regulated and closely coordinated with cell fate determination. Defects in cell shape are a hallmark of many pathological conditions including cancer and skin diseases. This review highlights the links between cell shape and cell fate in the epidermis, which have been studied for over 40 years both in vitro and in vivo. Briefly discussing seminal experiments showing the strong coupling between keratinocyte cell shape and their fate we primarily focus on recent studies uncovering novel cellular and molecular mechanisms linking epidermal cell shape with cell growth, differentiation, asymmetric division, and delamination.
动物细胞表现出多种多样的形状，反映了它们多样化的功能。细胞形状是由内部和外部力量之间的平衡决定的，因此涉及细胞骨架及其相关的粘附结构。在发育和稳态过程中，细胞形状的动态变化受到严格调控，并与细胞命运决定密切协调。细胞形状的缺陷是许多病理状况的标志，包括癌症和皮肤疾病。这篇综述强调了表皮细胞形状和细胞命运之间的联系，这些联系在过去 40 多年中无论是在体外还是在体内都得到了广泛的研究。简要讨论了一些开创性实验，这些实验表明角质形成细胞形状与其命运之间存在强烈的耦合，我们主要关注最近的研究，这些研究揭示了将表皮细胞形状与细胞生长、分化、不对称分裂和分层分离联系起来的新的细胞和分子机制。
