Ophthalmology, Retina, Asan Medical Center, University of Ulsan, Seoul, Republic of Korea.
Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Br J Ophthalmol. 2019 Dec;103(12):1759-1764. doi: 10.1136/bjophthalmol-2018-313596. Epub 2019 Mar 14.
BACKGROUND/AIM: To analyse ultrawide-field fluorescein angiography (UWF-FA) images of diabetic retinopathy using a novel software that automatically calculates microaneurysm (MA) and non-perfusion area.
Two hundred UWF-FA images of treatment-naïve diabetic retinopathy (38 proliferative diabetic retinopathy and 162 non-proliferative diabetic retinopathy) from 120 patients (mean age 54.22; 80 male) were analysed using novel software to determine the number of MAs, area of capillary non-perfusion (ischaemic index) and number of neovascularisations. Each result was compared according to its retinal regions.
For the total retina, the mean number of MAs was 292.02 (±175.57) and the ischaemic index was 59.42% (±14.78%). Most MAs were located in the mid-peripheral retina (80.54%); however, the density of MAs was highest in the posterior pole (p<0.001). The ischaemic index was highest in the peripheral retina (89.19%), followed by mid-periphery (50.65%) and posterior pole (1.85%). Patients with diabetic macular oedema (DME) presented more MA and a greater ischaemic index (p<0.001, each) than those without DME.
The automated software allowed prompt and quantitative analysis of UWF-FA images of DMR. MAs were most frequent in the nasal and mid-peripheral retina, with their density being highest in the posterior pole and nasal retina. Ischaemic index increased with distance from the posterior pole, showing strong correlation with central foveal thickness in all retinal areas except the posterior pole.
背景/目的：使用一种新的软件分析糖尿病视网膜病变的超广角荧光素血管造影（UWF-FA）图像，该软件可自动计算微动脉瘤（MA）和无灌注区。
对 120 例（平均年龄 54.22 岁；80 例男性）未经治疗的糖尿病视网膜病变（38 例增殖性糖尿病视网膜病变和 162 例非增殖性糖尿病视网膜病变）的 200 张 UWF-FA 图像进行了分析，使用新软件确定 MA 的数量、毛细血管无灌注区（缺血指数）的面积和新生血管的数量。根据视网膜区域比较每个结果。
对于整个视网膜，平均 MA 数量为 292.02（±175.57），缺血指数为 59.42%（±14.78%）。大多数 MA 位于中周部视网膜（80.54%）；然而，后极部 MA 的密度最高（p<0.001）。缺血指数在周边视网膜最高（89.19%），其次是中周部（50.65%）和后极部（1.85%）。与无糖尿病黄斑水肿（DME）的患者相比，有 DME 的患者的 MA 更多，缺血指数更高（均 p<0.001）。
自动软件可快速定量分析 DMR 的 UWF-FA 图像。MA 在鼻侧和中周部视网膜最常见，密度在后极部和鼻侧视网膜最高。缺血指数随距后极部距离的增加而增加，与除后极部以外的所有视网膜区域的中央凹厚度具有强烈相关性。
