Shen Hang-Qi, Wang Jing, Niu Tian, Chen Ji-Li, Xu Xun
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Int J Ophthalmol. 2021 Mar 18;14(3):409-415. doi: 10.18240/ijo.2021.03.13. eCollection 2021.
To analyze differences in ultra-widefield fluorescein angiography (UWFA) findings between dynamic and static images of eyes with diabetic retinopathy (DR).
This cross-sectional study included 28 eyes of 28 patients with DR undergoing UWFA. A series of UWFA images acquired from each patient were converted into a time-lapse video and used as a dynamic image. A single, clear, arteriovenous phase image was chosen as a static image. Non-perfusion index (NPI) and its correlation with vascular abnormalities in different zones were compared between dynamic and static UWFA imaging.
NPI appeared to increase from the center to the far-periphery in both groups. Dynamic NPI was lower in the total retinal area (0.26 0.29, =0.009) and far-periphery (0.33 0.36, adjusted =0.042), which was contrary to the static NPI. Far-peripheral NPI was associated with intraretinal microvascular abnormality in the posterior area in both groups.
Time-lapse dynamic UWFA imaging is a useful modality to differentially diagnose hypofluorescence in the most peripheral region. This modality could provide a reliable method for NPI measurement.
分析糖尿病视网膜病变（DR）患者眼睛的超广角荧光血管造影（UWFA）动态图像和静态图像结果的差异。
这项横断面研究纳入了28例接受UWFA检查的DR患者的28只眼睛。将从每位患者获取的一系列UWFA图像转换为延时视频并用作动态图像。选择一张清晰的动静脉期图像作为静态图像。比较动态和静态UWFA成像之间的无灌注指数（NPI）及其与不同区域血管异常的相关性。
两组中NPI似乎从中心到远周边部均增加。视网膜总面积（0.26±0.29，P = 0.009）和远周边部（0.33±0.36，校正后P = 0.042）的动态NPI较低，这与静态NPI相反。两组中远周边部NPI均与后部区域的视网膜内微血管异常相关。
延时动态UWFA成像是鉴别诊断最周边区域低荧光的有用方法。这种方法可为NPI测量提供可靠手段。
