糖尿病性黄斑水肿中微动脉瘤和毛细血管无灌注区的特征分布。

Characteristic distribution of microaneurysms and capillary dropouts in diabetic macular edema.

机构信息

Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Eiheiji-cho, Yoshida-gun, Fukui-ken, 910-1193, Japan.

Department of Ophthalmology, Laboratory of Ocular Cell Biology and Visual Science, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

出版信息

Graefes Arch Clin Exp Ophthalmol. 2020 Aug;258(8):1625-1630. doi: 10.1007/s00417-020-04722-8. Epub 2020 May 4.

DOI:10.1007/s00417-020-04722-8

PMID:32367289

Abstract

PURPOSE

To investigate the distribution pattern of microaneurysms (MAs) and capillary dropouts (CDOs) related to retinal thickness in patients with diabetic macular edema (DME).

METHODS

We designed a cross-sectional observational study in which we manually merged fluorescein angiography and optical coherence tomography (OCT) map and located MAs and CDOs areas. The density of MAs, the width and the length of circumference of CDOs, and the number of MAs adjacent to CDOs were compared between highly thickened (white area (WA) in OCT map) and border areas (red area (RA)).

RESULTS

We examined 115 eyes of 115 patients with DME. The density of MAs in RA (1.086 ± 0.616) was significantly higher than that in WA (0.8601 ± 1.086) (p = 0.002). The MA rates adjacent to CDOs in WA and RA were 79.1% and 80.7%, respectively. In the RA, the size of CDO adjacent to MAs was smaller (p = 0.013), but its circumference was longer (p = 0.018), and the number of MAs adjacent to CDOs was larger than those in WA (p = 0.002). The total length of circumference of CDOs was significantly correlated with the number of MAs adjacent to CDOs in WA (p = 0.011, R = 0.68) and RA (p = 0.008, R = 0.81).

CONCLUSION

Smaller but more CDOs with longer circumference adjacent to MAs contribute to the higher density of MAs in the surrounding areas of DME.

摘要

目的

研究糖尿病黄斑水肿（DME）患者视网膜厚度相关的微动脉瘤（MAs）和毛细血管无灌注（CDOs）的分布模式。

方法

我们设计了一项横断面观察性研究，手动合并荧光素血管造影和光学相干断层扫描（OCT）图，并定位 MA 和 CDO 区域。比较高度增厚（OCT 图中的白色区域（WA））和边界区域（红色区域（RA））中 MA 的密度、CDO 的周长宽度和长度以及与 CDO 相邻的 MA 数量。

结果

我们检查了 115 例 DME 患者的 115 只眼。RA 中的 MA 密度（1.086±0.616）明显高于 WA（0.8601±1.086）（p=0.002）。WA 和 RA 中 MA 与 CDO 相邻的 MA 率分别为 79.1%和 80.7%。在 RA 中，与 MA 相邻的 CDO 尺寸较小（p=0.013），但其周长较长（p=0.018），与 CDO 相邻的 MA 数量也大于 WA（p=0.002）。WA 中 CDO 总周长与与 CDO 相邻的 MA 数量呈显著正相关（p=0.011，R=0.68），与 RA 中 CDO 总周长与与 CDO 相邻的 MA 数量呈显著正相关（p=0.008，R=0.81）。