Department of Infectious Diseases, Royal Stoke University Hospital, Stoke-on-Trent, UK
Imperial College Healthcare NHS Trust, London, UK.
Clin Med (Lond). 2019 Mar;19(2):127-128. doi: 10.7861/clinmedicine.19-2-127.
Flucloxacillin, a beta-lactam antibiotic, is a commonly prescribed antibiotic for the treatment of infections caused by staphylococci and streptococci, most notably Paracetamol is one of the most dispensed medications by NHS England and is used for the treatment of fever and pain. However most doctors are unaware that concurrent use of these drugs can cause a potentially fatal drug interaction due to pyroglutamic acidosis (PGA), also known as 5-oxoprolinaemia. PGA is a rare cause of raised anion gap metabolic acidosis due to disruption of the γ-glutamyl cycle. We report the case of a patient with multiple comorbidities who developed PGA due to coadministration of paracetamol and flucloxacillin.
氟氯西林，一种β-内酰胺类抗生素，是一种常用于治疗葡萄球菌和链球菌引起的感染的处方抗生素，尤其是对乙酰氨基酚。对乙酰氨基酚是英格兰国民保健制度（NHS England）开出的最常见药物之一，用于治疗发热和疼痛。然而，大多数医生都不知道，由于吡咯烷酮羧酸（PGA），也称为 5-氧脯氨酸血症，这些药物同时使用会引起潜在致命的药物相互作用。PGA 是由于γ-谷氨酰循环中断导致罕见的阴离子间隙代谢性酸中毒的原因。我们报告了一例患有多种合并症的患者，由于同时使用对乙酰氨基酚和氟氯西林而发生 PGA。
