Taiwo Y O, Levine J D
Brain Res. 1986 May 14;373(1-2):81-4. doi: 10.1016/0006-8993(86)90317-3.
Intrathecal administration of PGE2 and PGF2 alpha and intradermal administration of PGE2 but not PGF2 alpha, in low doses, produce hyperalgesia as measured by the Randall-Selitto paw-withdrawal test. Indomethacin (2 mg/kg, i.p.) prevented intrathecal PGF2 alpha, but not PGE2-induced hyperalgesia. We propose that the central nociceptive effects of PGF2 alpha are mediated, indirectly, by effecting the cyclo-oxygenation of arachidonic acid in the central nervous system.
鞘内注射前列腺素E2（PGE2）和前列腺素F2α（PGF2α）以及皮内注射低剂量的PGE2（而非PGF2α），通过兰德尔-塞利托（Randall-Selitto）足趾撤离试验测量，会产生痛觉过敏。吲哚美辛（2毫克/千克，腹腔注射）可预防鞘内注射PGF2α所致的痛觉过敏，但不能预防PGE2所致的痛觉过敏。我们认为，PGF2α的中枢伤害性作用是通过影响中枢神经系统中花生四烯酸的环氧化作用间接介导的。
