Boisson N, Chouaib S, Fradelizi D
C R Acad Sci III. 1986;302(11):409-14.
Donors from HLA genotyped families are extremely useful for immunogenetic studies. Analysis of the in vitro allogenic response of lymphocytes from HLA recombinant siblings can dissect the respective role of HLA class I and class II antigens for the lymphocyte activation. Using lymphocytes from such donors, we have demonstrated that IL2 production is triggered by HLA class II disparities (but not by HLA class I), HLA class I disparities can prime the cytotoxic T lymphocytes precursors inducing the IL2 receptor on the specific clones which will proliferate in presence of IL2 either from endogenous origin (in the case of HLA class II disparities) or from experimentally added IL2 in the culture.
来自 HLA 基因分型家族的供体对免疫遗传学研究极为有用。对 HLA 重组同胞淋巴细胞的体外同种异体反应进行分析，可剖析 HLA Ⅰ类和Ⅱ类抗原在淋巴细胞激活中的各自作用。利用这些供体的淋巴细胞，我们已证明，IL2 的产生是由 HLA Ⅱ类差异（而非 HLA Ⅰ类差异）触发的，HLA Ⅰ类差异可使细胞毒性 T 淋巴细胞前体致敏，从而在特定克隆上诱导出 IL2 受体，这些克隆在存在内源性来源（在 HLA Ⅱ类差异的情况下）或培养中实验添加的 IL2 时会增殖。
