Goyette Jesse, Gaus Katharina
EMBL Australia Node in Single Molecule Science, School of Medical Sciences, University of New South Wales, Sydney 2052, Australia; ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, Sydney 2052, Australia.
EMBL Australia Node in Single Molecule Science, School of Medical Sciences, University of New South Wales, Sydney 2052, Australia; ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, Sydney 2052, Australia.
Curr Opin Cell Biol. 2017 Feb;44:86-92. doi: 10.1016/j.ceb.2016.09.004. Epub 2016 Sep 22.
Due to recent technical developments in microscopy, huge advances have been made in our understanding of the architecture of the cell membrane. It is now well appreciated that nanoscale clustering is a common feature of membrane proteins. Many of these clusters have been implicated in signal initiation and integration platforms. However, the mechanisms that mediate the dynamic nanoscale arrangement of membrane proteins are not fully understood and could involve lipid domains, electrostatic interactions between proteins and lipid, protein scaffolding as well as purely mechanical processes. In this review we summarise these mechanisms giving rise to dynamic nanoscale protein reorganisation in the plasma membrane with reference to recent examples of immune receptor clustering to illustrate general principles.
由于显微镜技术的最新发展，我们对细胞膜结构的理解取得了巨大进展。现在人们已经充分认识到，纳米级聚集是膜蛋白的一个共同特征。其中许多聚集体与信号起始和整合平台有关。然而，介导膜蛋白动态纳米级排列的机制尚未完全明了，可能涉及脂类结构域、蛋白质与脂类之间的静电相互作用、蛋白质支架以及纯粹的机械过程。在这篇综述中，我们总结了导致质膜中动态纳米级蛋白质重组的这些机制，并参考免疫受体聚集的最新实例来说明一般原理。
